Gene description for Setd8
Gene name SET domain containing (lysine methyltransferase) 8
Gene symbol Setd8
Other names/aliases 2410195B05Rik
AA617402
AW536475
PR-SET7
Species Mus musculus
 Database cross references - Setd8
ExoCarta ExoCarta_67956
Entrez Gene 67956
UniProt Q2YDW7  
 Setd8 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Setd8
Molecular Function
    mRNA methyltransferase activity GO:0008174 IEA
    p53 binding GO:0002039 ISO
    S-methyltransferase activity GO:0008172 IEA
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    P-methyltransferase activity GO:0051994 IEA
    O-methyltransferase activity GO:0008171 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    methyltransferase activity GO:0008168 IEA
    monomethylamine methyltransferase activity GO:0043852 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    N-methyltransferase activity GO:0008170 IEA
    histone-lysine N-methyltransferase activity GO:0018024 ISO
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    tRNA methyltransferase activity GO:0008175 IEA
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    trimethylamine methyltransferase activity GO:0043834 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    protein-lysine N-methyltransferase activity GO:0016279 ISO
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    rRNA methyltransferase activity GO:0008649 IEA
    transcription corepressor activity GO:0003714 ISO
    DNA-methyltransferase activity GO:0009008 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    transferase activity GO:0016740 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    RNA methyltransferase activity GO:0008173 IEA
    protein methyltransferase activity GO:0008276 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    protein-arginine N-methyltransferase activity GO:0016274 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    C-methyltransferase activity GO:0008169 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    Se-methyltransferase activity GO:0051995 IEA
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
    lysine N-methyltransferase activity GO:0016278 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    cell division GO:0051301 IEA
    regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    peptidyl-lysine monomethylation GO:0018026 ISO
    methylation GO:0032259 IEA
    chromatin modification GO:0016568 IEA
    mitotic nuclear division GO:0007067 IEA
    cell cycle GO:0007049 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    histone lysine methylation GO:0034968 ISO
Subcellular Localization
    chromosome GO:0005694 IEA
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Setd8 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Setd8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Setd8 is involved
No pathways found





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