Gene description for Setd8
Gene name	SET domain containing (lysine methyltransferase) 8
Gene symbol	Setd8
Other names/aliases	2410195B05Rik AA617402 AW536475 PR-SET7
Species	Mus musculus
Database cross references - Setd8
ExoCarta	ExoCarta_67956
Vesiclepedia	VP_67956
Entrez Gene	67956
UniProt	Q2YDW7
Setd8 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Setd8

Molecular Function     transcription corepressor activity GO:0003714 ISO     protein binding GO:0005515 ISS     protein-lysine N-methyltransferase activity GO:0016279 ISO     protein-lysine N-methyltransferase activity GO:0016279 ISS     histone methyltransferase activity GO:0042054 ISO     histone methyltransferase activity GO:0042054 ISS     histone H4K20 methyltransferase activity GO:0042799 IBA     histone H4K20 methyltransferase activity GO:0042799 ISO     histone H4K20 monomethyltransferase activity GO:0140944 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     chromatin remodeling GO:0006338 IEA     regulation of transcription by RNA polymerase II GO:0006357 IBA     peptidyl-lysine monomethylation GO:0018026 ISO     peptidyl-lysine monomethylation GO:0018026 ISS     regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 IBA     regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 ISO     regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 ISS     negative regulation of DNA-templated transcription GO:0045892 ISO     cell division GO:0051301 IEA     negative regulation of double-strand break repair via homologous recombination GO:2000042 ISO Subcellular Localization     chromatin GO:0000785 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     nucleoplasm GO:0005654 ISO     chromosome GO:0005694 IEA     polytene chromosome GO:0005700 IBA     cytosol GO:0005829 ISO