Gene description for Nmb
Gene name neuromedin B
Gene symbol Nmb
Other names/aliases 3110023K12Rik
Species Mus musculus
 Database cross references - Nmb
ExoCarta ExoCarta_68039
Entrez Gene 68039
UniProt Q9CR53  
 Nmb identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nmb
Molecular Function
    neuromedin B receptor binding GO:0031710 ISO
Biological Process
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    positive regulation of hormone secretion GO:0046887 ISO
    arachidonic acid secretion GO:0050482 ISO
    negative regulation of hormone secretion GO:0046888 ISO
    glucose homeostasis GO:0042593 ISO
    neuropeptide signaling pathway GO:0007218 IEA
    positive regulation of cell proliferation GO:0008284 ISO
Subcellular Localization
    neuron projection GO:0043005 ISO
    extracellular region GO:0005576 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Nmb in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nmb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nmb is involved
PathwayEvidenceSource
G alpha (q) signalling events IEA Reactome
G alpha (q) signalling events IEA Reactome
Peptide ligand-binding receptors IEA Reactome





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