Gene description for Eppk1
Gene name epiplakin 1
Gene symbol Eppk1
Other names/aliases Eppk1-ps1
Species Rattus norvegicus
 Database cross references - Eppk1
ExoCarta ExoCarta_680860
Vesiclepedia VP_680860
Entrez Gene 680860
 Eppk1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Eppk1
Molecular Function
    structural molecule activity GO:0005198 IBA
    intermediate filament binding GO:0019215 ISO
    keratin filament binding GO:1990254 IBA
    keratin filament binding GO:1990254 ISO
Biological Process
    cytoskeleton organization GO:0007010 ISO
    negative regulation of keratinocyte proliferation GO:0010839 ISO
    negative regulation of cell migration GO:0030336 ISO
    regulation of epithelial cell differentiation GO:0030856 ISO
    wound healing GO:0042060 IBA
    wound healing GO:0042060 ISO
    intermediate filament organization GO:0045109 ISO
    intermediate filament bundle assembly GO:0045110 IBA
    intermediate filament bundle assembly GO:0045110 ISO
    negative regulation of epithelial cell proliferation GO:0050680 ISO
    negative regulation of keratinocyte migration GO:0051548 ISO
    positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 ISO
    negative regulation of wound healing GO:0061045 ISO
    regulation of epithelium regeneration GO:1905041 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 ISO
    cell-cell junction GO:0005911 ISO
    bicellular tight junction GO:0005923 ISO
    membrane GO:0016020 IBA
    apicolateral plasma membrane GO:0016327 ISO
    cell junction GO:0030054 IBA
    hemidesmosome GO:0030056 ISO
    cell projection GO:0042995 IEA
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
    basal part of cell GO:0045178 ISO
    cell periphery GO:0071944 ISO
    perinucleolar compartment GO:0097356 ISO
 Experiment description of studies that identified Eppk1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Eppk1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Eppk1 is involved
No pathways found





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