Gene description for Gcsh
Gene name glycine cleavage system protein H (aminomethyl carrier)
Gene symbol Gcsh
Other names/aliases 1100001L02Rik
5730591C18Rik
Species Mus musculus
 Database cross references - Gcsh
ExoCarta ExoCarta_68133
Vesiclepedia VP_68133
Entrez Gene 68133
UniProt Q91WK5  
 Gcsh identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Gcsh
Molecular Function
    aminomethyltransferase activity GO:0004047 ISO
    enzyme binding GO:0019899 ISO
Biological Process
    protein lipoylation GO:0009249 ISO
    protein lipoylation GO:0009249 ISS
    glycine decarboxylation via glycine cleavage system GO:0019464 IBA
    glycine decarboxylation via glycine cleavage system GO:0019464 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    glycine cleavage complex GO:0005960 IBA
    glycine cleavage complex GO:0005960 IEA
 Experiment description of studies that identified Gcsh in exosomes
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Gcsh
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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