Gene description for Ift80
Gene name intraflagellar transport 80
Gene symbol Ift80
Other names/aliases 4921524P20Rik
Wdr56
mKIAA1374
Species Mus musculus
 Database cross references - Ift80
ExoCarta ExoCarta_68259
Entrez Gene 68259
UniProt Q8K057  
 Ift80 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ift80
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    positive regulation of smoothened signaling pathway GO:0045880 IMP
    negative regulation of non-canonical Wnt signaling pathway GO:2000051 IGI
    bone morphogenesis GO:0060349 IMP
    cilium assembly GO:0042384 IMP
    chondrocyte differentiation GO:0002062 IMP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    intraciliary transport GO:0042073 IC
    cilium morphogenesis GO:0060271 IMP
    smoothened signaling pathway GO:0007224 IMP
    osteoblast differentiation GO:0001649 IMP
    nonmotile primary cilium assembly GO:0035058 IMP
Subcellular Localization
    intraciliary transport particle B GO:0030992 IDA
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IDA
    intracellular GO:0005622 IC
    cell projection GO:0042995 IEA
    cell GO:0005623 IC
    ciliary basal body GO:0036064 ISO
    cilium GO:0005929 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Ift80 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ift80
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ift80 is involved
PathwayEvidenceSource
Intraflagellar transport IEA Reactome





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