Gene description for Ift80
Gene name intraflagellar transport 80
Gene symbol Ift80
Other names/aliases 4921524P20Rik
Wdr56
mKIAA1374
Species Mus musculus
 Database cross references - Ift80
ExoCarta ExoCarta_68259
Vesiclepedia VP_68259
Entrez Gene 68259
UniProt Q8K057  
 Ift80 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ift80
Molecular Function
    molecular_function GO:0003674 ND
    protein binding GO:0005515 IPI
Biological Process
    skeletal system development GO:0001501 IMP
    ossification GO:0001503 IMP
    osteoblast differentiation GO:0001649 IGI
    osteoblast differentiation GO:0001649 IMP
    endochondral ossification GO:0001958 IMP
    chondrocyte differentiation GO:0002062 IGI
    chondrocyte differentiation GO:0002062 IMP
    growth plate cartilage development GO:0003417 IMP
    growth plate cartilage chondrocyte differentiation GO:0003418 IMP
    apoptotic process GO:0006915 IMP
    establishment or maintenance of cell polarity GO:0007163 IMP
    smoothened signaling pathway GO:0007224 IMP
    canonical NF-kappaB signal transduction GO:0007249 IMP
    cell population proliferation GO:0008283 IMP
    fibroblast growth factor receptor signaling pathway GO:0008543 IMP
    tissue development GO:0009888 IMP
    gene expression GO:0010467 IMP
    proteasomal protein catabolic process GO:0010498 IMP
    negative regulation of keratinocyte proliferation GO:0010839 IMP
    protein ubiquitination GO:0016567 IMP
    spinal cord development GO:0021510 IMP
    osteoclast differentiation GO:0030316 IMP
    osteoblast proliferation GO:0033687 IMP
    multicellular organism growth GO:0035264 IMP
    non-canonical Wnt signaling pathway GO:0035567 IGI
    bone mineralization involved in bone maturation GO:0035630 IMP
    intraciliary anterograde transport GO:0035720 NAS
    intraciliary transport GO:0042073 IC
    odontogenesis GO:0042476 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP
    keratinocyte proliferation GO:0043616 IMP
    tooth eruption GO:0044691 IMP
    cilium organization GO:0044782 IMP
    stem cell differentiation GO:0048863 IMP
    protein stabilization GO:0050821 IMP
    cartilage development GO:0051216 IMP
    limb development GO:0060173 IMP
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 IMP
    cilium assembly GO:0060271 NAS
    bone development GO:0060348 IMP
    bone morphogenesis GO:0060349 IMP
    articular cartilage development GO:0061975 IMP
    odontoblast differentiation GO:0071895 IMP
    stem cell proliferation GO:0072089 IMP
    receptor localization to non-motile cilium GO:0097500 IMP
    response to inositol GO:1902140 IDA
    non-motile cilium assembly GO:1905515 IMP
    non-motile cilium assembly GO:1905515 IMP
    cartilage homeostasis GO:1990079 IMP
    negative regulation of non-canonical Wnt signaling pathway GO:2000051 IGI
Subcellular Localization
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    cilium GO:0005929 IBA
    cilium GO:0005929 IDA
    cilium GO:0005929 NAS
    cilium GO:0005929 TAS
    intraciliary transport particle B GO:0030992 IBA
    intraciliary transport particle B GO:0030992 IDA
    intraciliary transport particle B GO:0030992 ISO
    ciliary basal body GO:0036064 IDA
    ciliary basal body GO:0036064 ISO
    9+0 non-motile cilium GO:0097731 IDA
 Experiment description of studies that identified Ift80 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ift80
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ttc30a2  
Co-fractionation Mus musculus
2 Kif17  
Co-fractionation Mus musculus
3 Ift88  
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
4 Plxna2  
Co-fractionation Mus musculus
5 Ttc26  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Ift80 is involved
PathwayEvidenceSource
Cilium Assembly IEA Reactome
Intraflagellar transport IEA Reactome
Organelle biogenesis and maintenance IEA Reactome





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