Gene description for Mat2b
Gene name methionine adenosyltransferase II, beta
Gene symbol Mat2b
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Mat2b
ExoCarta ExoCarta_683630
Entrez Gene 683630
UniProt Q5U2R0  
 Mat2b identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Mat2b
Molecular Function
    methionine adenosyltransferase regulator activity GO:0048270 ISO
    enzyme binding GO:0019899 ISO
    molecular_function GO:0003674 ND
Biological Process
    regulation of catalytic activity GO:0050790 ISO
    one-carbon metabolic process GO:0006730 IEA
    biological_process GO:0008150 ND
    S-adenosylmethionine biosynthetic process GO:0006556 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    cellular_component GO:0005575 ND
    methionine adenosyltransferase complex GO:0048269 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Mat2b in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Mat2b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mat2b is involved
PathwayEvidenceSource
Methylation IEA Reactome





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