Gene description for Oxct1
Gene name 3-oxoacid CoA transferase 1
Gene symbol Oxct1
Other names/aliases SCOT
Species Rattus norvegicus
 Database cross references - Oxct1
ExoCarta ExoCarta_690163
Vesiclepedia VP_690163
Entrez Gene 690163
UniProt B2GV06  
 Oxct1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Oxct1
Molecular Function
    succinyl-CoA:3-oxo-acid CoA-transferase activity GO:0008260 IBA
    succinyl-CoA:3-oxo-acid CoA-transferase activity GO:0008260 IDA
    succinyl-CoA:3-oxo-acid CoA-transferase activity GO:0008260 IEA
    succinyl-CoA:3-oxo-acid CoA-transferase activity GO:0008260 ISO
    CoA-transferase activity GO:0008410 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 ISO
Biological Process
    heart development GO:0007507 IEP
    response to nutrient GO:0007584 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    response to hormone GO:0009725 IEP
    response to activity GO:0014823 IEP
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP
    ketone catabolic process GO:0042182 IEA
    ketone catabolic process GO:0042182 ISO
    response to starvation GO:0042594 IEP
    response to ethanol GO:0045471 IEP
    ketone body catabolic process GO:0046952 IEA
    ketone body catabolic process GO:0046952 ISO
    adipose tissue development GO:0060612 IEP
    ketone body metabolic process GO:1902224 IBA
Subcellular Localization
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Oxct1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Oxct1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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