Gene description for Hint1
Gene name histidine triad nucleotide binding protein 1
Gene symbol Hint1
Other names/aliases Pkci
Prkci
Species Rattus norvegicus
 Database cross references - Hint1
ExoCarta ExoCarta_690660
Entrez Gene 690660
UniProt P62959  
 Hint1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Hint1
Molecular Function
    nucleotide binding GO:0000166 IEA
    hydrolase activity GO:0016787 ISS
Biological Process
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 ISS
    transcription, DNA-templated GO:0006351 IEA
    purine ribonucleotide catabolic process GO:0009154 ISS
    regulation of transcription, DNA-templated GO:0006355 ISS
Subcellular Localization
    histone deacetylase complex GO:0000118 ISS
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Hint1 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Hint1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hint1 is involved
No pathways found





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