Gene description for MGC112715
Gene name hypothetical protein LOC690899
Gene symbol MGC112715
Other names/aliases -
Species Rattus norvegicus
 Database cross references - MGC112715
ExoCarta ExoCarta_690899
Vesiclepedia VP_690899
Entrez Gene 690899
 MGC112715 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for MGC112715
Molecular Function
    enzyme binding GO:0019899 ISO
    identical protein binding GO:0042802 ISO
    endopeptidase activator activity GO:0061133 ISO
Biological Process
    negative regulation of T cell cytokine production GO:0002725 ISO
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of endopeptidase activity GO:0010950 ISO
    positive regulation of cell migration GO:0030335 ISO
    BMP signaling pathway GO:0030509 ISO
    BMP signaling pathway GO:0030509 ISO
    positive regulation of BMP signaling pathway GO:0030513 ISO
    zymogen activation GO:0031638 ISO
    negative regulation of type II interferon production GO:0032689 ISO
    negative regulation of interleukin-10 production GO:0032693 ISO
    negative regulation of interleukin-17 production GO:0032700 ISO
    negative regulation of tumor necrosis factor production GO:0032720 ISO
    positive regulation of regulatory T cell differentiation GO:0045591 ISO
    negative regulation of alpha-beta T cell activation GO:0046636 IBA
    stem cell differentiation GO:0048863 ISO
    stem cell differentiation GO:0048863 ISO
    positive regulation of collagen catabolic process GO:0120158 ISO
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 ISO
    negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000562 ISO
    negative regulation of CD8-positive, alpha-beta T cell proliferation GO:2000565 ISO
    positive regulation of stem cell differentiation GO:2000738 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 ISO
 Experiment description of studies that identified MGC112715 in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for MGC112715
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MGC112715 is involved
No pathways found





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