Gene description for Kmt2e
Gene name lysine (K)-specific methyltransferase 2E
Gene symbol Kmt2e
Other names/aliases 1810033J14Rik
9530077A04Rik
D230038D11Rik
Mll5
NKp44L
Species Mus musculus
 Database cross references - Kmt2e
ExoCarta ExoCarta_69188
Vesiclepedia VP_69188
Entrez Gene 69188
UniProt Q3UG20  
 Kmt2e identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Kmt2e
Molecular Function
    transcription coactivator activity GO:0003713 ISO
    transcription coactivator activity GO:0003713 ISS
    enzyme binding GO:0019899 IEA
    enzyme binding GO:0019899 ISO
    methylated histone binding GO:0035064 IBA
    methylated histone binding GO:0035064 IEA
    methylated histone binding GO:0035064 ISO
    histone H3K4 methyltransferase activity GO:0042800 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    neutrophil mediated immunity GO:0002446 IMP
    regulation of DNA-templated transcription GO:0006355 IBA
    erythrocyte differentiation GO:0030218 IMP
    epigenetic regulation of gene expression GO:0040029 IMP
    neutrophil activation GO:0042119 IMP
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of DNA-templated transcription GO:0045893 ISS
    retinoic acid receptor signaling pathway GO:0048384 ISS
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 ISO
Subcellular Localization
    chromatin GO:0000785 ISO
    euchromatin GO:0000791 IEA
    euchromatin GO:0000791 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IEA
    nuclear body GO:0016604 ISO
    nuclear speck GO:0016607 IEA
    protein-containing complex GO:0032991 IEA
    protein-containing complex GO:0032991 ISO
    Set3 complex GO:0034967 IBA
    Rpd3L-Expanded complex GO:0070210 IBA
 Experiment description of studies that identified Kmt2e in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Kmt2e
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cyld  
Co-fractionation Mus musculus
2 Trp53  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
3 Tbc1d1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Kmt2e is involved
No pathways found





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