Gene description for Bst2
Gene name bone marrow stromal cell antigen 2
Gene symbol Bst2
Other names/aliases 2310015I10Rik
Bst-2
C87040
CD317
DAMP-1
GREG
Species Mus musculus
 Database cross references - Bst2
ExoCarta ExoCarta_69550
Vesiclepedia VP_69550
Entrez Gene 69550
UniProt Q8R2Q8  
 Bst2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Bst2
Molecular Function
    metalloendopeptidase inhibitor activity GO:0008191 IBA
    metalloendopeptidase inhibitor activity GO:0008191 ISO
    metalloendopeptidase inhibitor activity GO:0008191 ISS
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    negative regulation of plasmacytoid dendritic cell cytokine production GO:0002737 ISO
    negative regulation of plasmacytoid dendritic cell cytokine production GO:0002737 ISS
    response to virus GO:0009615 IDA
    response to virus GO:0009615 ISO
    negative regulation of cell growth GO:0030308 ISO
    negative regulation of cell growth GO:0030308 ISS
    negative regulation of cell migration GO:0030336 ISO
    negative regulation of cell migration GO:0030336 ISS
    regulation of actin cytoskeleton organization GO:0032956 ISO
    regulation of actin cytoskeleton organization GO:0032956 ISS
    response to type II interferon GO:0034341 IDA
    response to interferon-alpha GO:0035455 IDA
    response to interferon-beta GO:0035456 IDA
    negative regulation of viral genome replication GO:0045071 IMP
    negative regulation of viral genome replication GO:0045071 ISO
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IMP
    innate immune response GO:0045087 ISO
    defense response to virus GO:0051607 IBA
    defense response to virus GO:0051607 IEA
    defense response to virus GO:0051607 ISO
    negative regulation of intracellular transport of viral material GO:1901253 IDA
    negative regulation of intracellular transport of viral material GO:1901253 IMP
    negative regulation of intracellular transport of viral material GO:1901253 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    late endosome GO:0005770 IEA
    multivesicular body GO:0005771 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    apical plasma membrane GO:0016324 ISO
    apical plasma membrane GO:0016324 ISS
    intracellular membrane-bounded organelle GO:0043231 ISO
    membrane raft GO:0045121 IEA
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified Bst2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Bst2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bst2 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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