Gene description for Pin4
Gene name protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
Gene symbol Pin4
Other names/aliases 2410002I22Rik
EPVH
Par14
Species Mus musculus
 Database cross references - Pin4
ExoCarta ExoCarta_69713
Entrez Gene 69713
UniProt Q9CWW6  
 Pin4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pin4
Molecular Function
    DNA binding GO:0003677 IEA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IEA
    bent DNA binding GO:0003681 ISO
    isomerase activity GO:0016853 IEA
    poly(A) RNA binding GO:0044822 ISO
    double-stranded DNA binding GO:0003690 ISO
Biological Process
    rRNA processing GO:0006364 ISO
Subcellular Localization
    spindle GO:0005819 ISO
    mitochondrial matrix GO:0005759 ISO
    cytoskeleton GO:0005856 IEA
    nucleolus GO:0005730 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    preribosome GO:0030684 ISO
 Experiment description of studies that identified Pin4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pin4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pin4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here