Gene description for Rap2c
Gene name RAP2C, member of RAS oncogene family
Gene symbol Rap2c
Other names/aliases 2010200P20Rik
AI194294
AL022976
Species Mus musculus
 Database cross references - Rap2c
ExoCarta ExoCarta_72065
Entrez Gene 72065
UniProt Q8BU31  
 Rap2c identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
 Gene ontology annotations for Rap2c
Molecular Function
    GTP binding GO:0005525 ISO
    transcription coactivator activity GO:0003713 ISO
    GDP binding GO:0019003 ISO
    nucleotide binding GO:0000166 IEA
Biological Process
    regulation of nucleic acid-templated transcription GO:1903506 ISO
    signal transduction GO:0007165 IEA
    small GTPase mediated signal transduction GO:0007264 IEA
    establishment of endothelial intestinal barrier GO:0090557 ISO
    Rap protein signal transduction GO:0032486 IDA
    negative regulation of cell migration GO:0030336 IDA
    regulation of protein tyrosine kinase activity GO:0061097 IDA
    positive regulation of protein autophosphorylation GO:0031954 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IDA
    cell-cell contact zone GO:0044291 ISO
    recycling endosome membrane GO:0055038 IDA
    bicellular tight junction GO:0005923 ISO
    plasma membrane GO:0005886 ISO
    recycling endosome GO:0055037 IDA
    endosome GO:0005768 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified Rap2c in exosomes
1
Experiment ID 73
ISEV standards
EM
EV Biophysical techniques
HSP70|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
 Protein-protein interactions for Rap2c
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rap2c is involved
No pathways found





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