Gene description for Mvb12b
Gene name multivesicular body subunit 12B
Gene symbol Mvb12b
Other names/aliases 2610200O14Rik
2610528K11Rik
AI414895
Fam125b
Species Mus musculus
 Database cross references - Mvb12b
ExoCarta ExoCarta_72543
Vesiclepedia VP_72543
Entrez Gene 72543
UniProt Q6KAU4  
 Mvb12b identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mvb12b
Molecular Function
    lipid binding GO:0008289 IEA
    lipid binding GO:0008289 ISO
Biological Process
    protein transport GO:0015031 IEA
    virus maturation GO:0019075 IBA
    virus maturation GO:0019075 IEA
    virus maturation GO:0019075 ISO
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IBA
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IEA
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 ISO
    viral budding GO:0046755 IBA
    viral budding GO:0046755 IEA
    viral budding GO:0046755 ISO
Subcellular Localization
    ESCRT I complex GO:0000813 IBA
    ESCRT I complex GO:0000813 IEA
    ESCRT I complex GO:0000813 ISO
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    early endosome GO:0005769 IEA
    early endosome GO:0005769 ISO
    late endosome GO:0005770 IBA
    late endosome GO:0005770 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    late endosome membrane GO:0031902 IEA
    vesicle GO:0031982 ISO
 Experiment description of studies that identified Mvb12b in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mvb12b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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