Gene description for Pan3
Gene name PAN3 polyA specific ribonuclease subunit homolog (S. cerevisiae)
Gene symbol Pan3
Other names/aliases 2700050F09Rik
A430027N15Rik
AU014670
Species Mus musculus
 Database cross references - Pan3
ExoCarta ExoCarta_72587
Vesiclepedia VP_72587
Entrez Gene 72587
UniProt Q640Q5  
 Pan3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pan3
Molecular Function
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    poly(A)-specific ribonuclease activity GO:0004535 ISO
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290 IMP
    mRNA processing GO:0006397 IEA
    positive regulation of cytoplasmic mRNA processing body assembly GO:0010606 IMP
    protein targeting GO:0006605 IDA
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoplasmic mRNA processing body GO:0000932 IDA
    PAN complex GO:0031251 ISO
 Experiment description of studies that identified Pan3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pan3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pan3 is involved
PathwayEvidenceSource
Deadenylation of mRNA IEA Reactome





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