Gene description for Emc7
Gene name ER membrane protein complex subunit 7
Gene symbol Emc7
Other names/aliases 2900064A13Rik
AI451465
ORF3
c11orf3
Species Mus musculus
 Database cross references - Emc7
ExoCarta ExoCarta_73024
Vesiclepedia VP_73024
Entrez Gene 73024
UniProt Q9EP72  
 Emc7 identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Emc7
Molecular Function
    carbohydrate binding GO:0030246 IEA
    membrane insertase activity GO:0032977 ISO
    membrane insertase activity GO:0032977 ISS
Biological Process
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 ISO
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 ISS
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISO
    tail-anchored membrane protein insertion into ER membrane GO:0071816 ISS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum membrane GO:0005789 ISS
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    EMC complex GO:0072546 IBA
    EMC complex GO:0072546 ISO
    EMC complex GO:0072546 ISS
 Experiment description of studies that identified Emc7 in sEVs
1
Experiment ID 264
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Emc7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Emc7 is involved
No pathways found





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