Gene description for Tmed5
Gene name transmembrane emp24 protein transport domain containing 5
Gene symbol Tmed5
Other names/aliases 3110020O18Rik
4432412D15Rik
Species Mus musculus
 Database cross references - Tmed5
ExoCarta ExoCarta_73130
Entrez Gene 73130
UniProt Q9CXE7  
 Tmed5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tmed5
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    Golgi ribbon formation GO:0090161 ISO
    transport GO:0006810 IEA
    protein transport GO:0015031 IEA
Subcellular Localization
    endoplasmic reticulum exit site GO:0070971 ISO
    membrane GO:0016020 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
    cis-Golgi network GO:0005801 ISO
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum GO:0005783 IEA
    Golgi apparatus GO:0005794 IEA
 Experiment description of studies that identified Tmed5 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tmed5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmed5 is involved
PathwayEvidenceSource
WNT ligand biogenesis and trafficking IEA Reactome





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