Gene description for UMOD
Gene name	uromodulin
Gene symbol	UMOD
Other names/aliases	ADMCKD2 FJHN HNFJ HNFJ1 MCKD2 THGP THP
Species	Homo sapiens
Database cross references - UMOD
ExoCarta	ExoCarta_7369
Vesiclepedia	VP_7369
Entrez Gene	7369
HGNC	12559
MIM	191845
UniProt	P07911
UMOD identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Urine	15326289
Urine	19056867
Urine	21595033
Urine	21595033
Urine	21595033
Urine	22418980
Urine	22418980
Urine	25452312
Urine	33432243
Urine	33432243
Urine	33432243

Gene ontology annotations for UMOD

Molecular Function     calcium ion binding GO:0005509 IEA     protein binding GO:0005515 IPI     IgG binding GO:0019864 IDA Biological Process     organ or tissue specific immune response GO:0002251 IEA     renal water homeostasis GO:0003091 IEA     glomerular filtration GO:0003094 IEA     lipid metabolic process GO:0006629 IEA     intracellular calcium ion homeostasis GO:0006874 IEA     intracellular sodium ion homeostasis GO:0006883 IEA     autophagy GO:0006914 IEA     inflammatory response GO:0006954 IEA     cellular defense response GO:0006968 TAS     endoplasmic reticulum organization GO:0007029 IEA     heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA     leukocyte cell-cell adhesion GO:0007159 IDA     regulation of blood pressure GO:0008217 IEA     negative regulation of cell population proliferation GO:0008285 TAS     RNA splicing GO:0008380 IEA     response to xenobiotic stimulus GO:0009410 IEA     response to water deprivation GO:0009414 IEA     urate transport GO:0015747 IEA     intracellular phosphate ion homeostasis GO:0030643 IEA     intracellular chloride ion homeostasis GO:0030644 IEA     response to lipopolysaccharide GO:0032496 IEA     tumor necrosis factor-mediated signaling pathway GO:0033209 IEA     multicellular organismal response to stress GO:0033555 IEA     cellular response to unfolded protein GO:0034620 IEA     regulation of urine volume GO:0035809 IEA     ERAD pathway GO:0036503 IEA     protein transport into plasma membrane raft GO:0044861 IEA     citric acid secretion GO:0046720 IEA     defense response to Gram-negative bacterium GO:0050829 IDA     regulation of protein transport GO:0051223 IEA     potassium ion homeostasis GO:0055075 IEA     micturition GO:0060073 IEA     chaperone-mediated protein folding GO:0061077 IEA     renal sodium ion absorption GO:0070294 IEA     urea transmembrane transport GO:0071918 IEA     collecting duct development GO:0072044 IEA     juxtaglomerular apparatus development GO:0072051 IEA     metanephric ascending thin limb development GO:0072218 IEA     metanephric distal convoluted tubule development GO:0072221 IEA     metanephric thick ascending limb development GO:0072233 IEA     protein localization to vacuole GO:0072665 IEA     apoptotic signaling pathway GO:0097190 IEA     connective tissue replacement GO:0097709 IEA     renal urate salt excretion GO:0097744 IEA     antibacterial innate immune response GO:0140367 IDA     neutrophil migration GO:1990266 IBA     neutrophil migration GO:1990266 IDA Subcellular Localization     spindle pole GO:0000922 IDA     extracellular space GO:0005615 IBA     endoplasmic reticulum GO:0005783 IEA     Golgi lumen GO:0005796 TAS     cilium GO:0005929 IDA     cell surface GO:0009986 IBA     membrane GO:0016020 IDA     basolateral plasma membrane GO:0016323 IDA     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IDA     extrinsic component of membrane GO:0019898 TAS     ciliary membrane GO:0060170 IEA     extracellular exosome GO:0070062 HDA     side of membrane GO:0098552 IEA