Gene description for Steap2
Gene name six transmembrane epithelial antigen of prostate 2
Gene symbol Steap2
Other names/aliases 4921538B17Rik
AI930049
AW045895
IPCA-1
IPCA1
PCANAP1
STAMP1
STMP
Species Mus musculus
 Database cross references - Steap2
ExoCarta ExoCarta_74051
Vesiclepedia VP_74051
Entrez Gene 74051
UniProt Q8BWB6  
 Steap2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Steap2
Molecular Function
    cupric reductase (NADH) activity GO:0008823 IBA
    cupric reductase (NADH) activity GO:0008823 IDA
    metal ion binding GO:0046872 IEA
    ferric-chelate reductase (NADPH) activity GO:0052851 IBA
    ferric-chelate reductase (NADPH) activity GO:0052851 IDA
Biological Process
    Golgi to plasma membrane transport GO:0006893 ISO
    Golgi to plasma membrane transport GO:0006893 ISS
    endocytosis GO:0006897 ISO
    endocytosis GO:0006897 ISS
    response to hormone GO:0009725 ISO
    response to hormone GO:0009725 ISS
    copper ion import GO:0015677 IBA
    copper ion import GO:0015677 IDA
    regulated exocytosis GO:0045055 ISO
    regulated exocytosis GO:0045055 ISS
    copper ion import across plasma membrane GO:0098705 IDA
    iron ion import across cell outer membrane GO:0098706 IDA
    iron ion import across plasma membrane GO:0098711 IDA
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    early endosome GO:0005769 ISO
    early endosome GO:0005769 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    endosome membrane GO:0010008 IEA
    trans-Golgi network transport vesicle GO:0030140 ISO
    trans-Golgi network transport vesicle GO:0030140 ISS
 Experiment description of studies that identified Steap2 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Steap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nphs2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Steap2 is involved
No pathways found





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