Gene description for Plce1
Gene name	phospholipase C, epsilon 1
Gene symbol	Plce1
Other names/aliases	4933403A21Rik PLCepsilon Plce mKIAA1516
Species	Mus musculus
Database cross references - Plce1
ExoCarta	ExoCarta_74055
Vesiclepedia	VP_74055
Entrez Gene	74055
UniProt	Q8K4S1
Plce1 identified in sEVs derived from the following tissue/cell type
Basophilic leukemia cells	20424270
Mast cells	17486113

Gene ontology annotations for Plce1

Molecular Function     phosphatidylinositol phospholipase C activity GO:0004435 IBA     phosphatidylinositol phospholipase C activity GO:0004435 ISO     phosphatidylinositol phospholipase C activity GO:0004435 ISS     phospholipase C activity GO:0004629 ISO     phospholipase C activity GO:0004629 ISS     guanyl-nucleotide exchange factor activity GO:0005085 IEA     protein binding GO:0005515 IPI     enzyme binding GO:0019899 ISO     enzyme binding GO:0019899 ISS     small GTPase binding GO:0031267 ISO     metal ion binding GO:0046872 IEA Biological Process     diacylglycerol biosynthetic process GO:0006651 ISO     diacylglycerol biosynthetic process GO:0006651 ISS     epidermal growth factor receptor signaling pathway GO:0007173 ISO     epidermal growth factor receptor signaling pathway GO:0007173 ISS     G protein-coupled receptor signaling pathway GO:0007186 IBA     G protein-coupled receptor signaling pathway GO:0007186 ISO     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISO     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISS     small GTPase-mediated signal transduction GO:0007264 IEA     Ras protein signal transduction GO:0007265 IBA     Ras protein signal transduction GO:0007265 ISO     positive regulation of lamellipodium assembly GO:0010592 ISO     positive regulation of lamellipodium assembly GO:0010592 ISS     lipid catabolic process GO:0016042 IEA     glomerulus development GO:0032835 ISO     intracellular signal transduction GO:0035556 ISO     intracellular signal transduction GO:0035556 ISS     phosphatidylinositol metabolic process GO:0046488 IBA     phosphatidylinositol-mediated signaling GO:0048015 IBA     release of sequestered calcium ion into cytosol GO:0051209 IBA Subcellular Localization     Golgi membrane GO:0000139 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     lamellipodium GO:0030027 ISO     lamellipodium GO:0030027 ISS