Gene description for Actr3
Gene name ARP3 actin-related protein 3
Gene symbol Actr3
Other names/aliases 1200003A09Rik
Arp3
Species Mus musculus
 Database cross references - Actr3
ExoCarta ExoCarta_74117
Entrez Gene 74117
UniProt Q99JY9  
 Actr3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Actr3
Molecular Function
    structural constituent of cytoskeleton GO:0005200 ISO
    actin filament binding GO:0051015 ISO
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    actin binding GO:0003779 IEA
Biological Process
    actin filament organization GO:0007015 IEA
    positive regulation of filopodium assembly GO:0051491 ISO
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
    asymmetric cell division GO:0008356 IGI
    positive regulation of dendrite morphogenesis GO:0050775 ISO
    positive regulation of neuron differentiation GO:0045666 ISO
    establishment or maintenance of cell polarity GO:0007163 IGI
    meiotic cell cycle GO:0051321 IGI
    meiotic chromosome movement towards spindle pole GO:0016344 IGI
    cilium morphogenesis GO:0060271 ISO
    meiotic cytokinesis GO:0033206 IGI
    positive regulation of actin filament polymerization GO:0030838 ISO
    cell projection organization GO:0030030 IEA
    spindle localization GO:0051653 IGI
    regulation of myosin II filament organization GO:0043519 ISO
    positive regulation of lamellipodium assembly GO:0010592 ISO
Subcellular Localization
    lamellipodium GO:0030027 ISO
    focal adhesion GO:0005925 ISO
    cell projection GO:0042995 IEA
    extracellular exosome GO:0070062 ISO
    hemidesmosome GO:0030056 ISO
    cytoplasm GO:0005737 ISO
    cell leading edge GO:0031252 ISO
    excitatory synapse GO:0060076 ISO
    podosome GO:0002102 ISO
    Golgi membrane GO:0000139 ISO
    cytoskeleton GO:0005856 IEA
    cell GO:0005623 IGI
    brush border GO:0005903 IDA
    membrane GO:0016020 ISO
    cell-cell junction GO:0005911 IDA
    actin filament GO:0005884 ISO
    Arp2/3 protein complex GO:0005885 ISO
 Experiment description of studies that identified Actr3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Actr3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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