Gene description for Dhcr24
Gene name 24-dehydrocholesterol reductase
Gene symbol Dhcr24
Other names/aliases 2310076D10Rik
5830417J06Rik
mKIAA0018
Species Mus musculus
 Database cross references - Dhcr24
ExoCarta ExoCarta_74754
Entrez Gene 74754
UniProt Q8VCH6  
 Dhcr24 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Dhcr24
Molecular Function
    oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 ISO
    enzyme binding GO:0019899 ISO
    delta24(24-1) sterol reductase activity GO:0000246 ISO
    oxidoreductase activity GO:0016491 IEA
    peptide antigen binding GO:0042605 ISO
    flavin adenine dinucleotide binding GO:0050660 IEA
    delta24-sterol reductase activity GO:0050614 IEA
    catalytic activity GO:0003824 IEA
    UDP-N-acetylmuramate dehydrogenase activity GO:0008762 IEA
    oxidoreductase activity, acting on CH-OH group of donors GO:0016614 IEA
Biological Process
    amyloid precursor protein catabolic process GO:0042987 IMP
    skin development GO:0043588 IMP
    lipid metabolic process GO:0006629 IEA
    tissue development GO:0009888 ISO
    steroid metabolic process GO:0008202 ISO
    Ras protein signal transduction GO:0007265 ISO
    steroid biosynthetic process GO:0006694 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    cholesterol metabolic process GO:0008203 IMP
    male genitalia development GO:0030539 IMP
    sterol biosynthetic process GO:0016126 IEA
    negative regulation of cell proliferation GO:0008285 ISO
    sterol metabolic process GO:0016125 IMP
    plasminogen activation GO:0031639 IMP
    cholesterol biosynthetic process GO:0006695 ISO
    membrane organization GO:0061024 IMP
    protein localization GO:0008104 IMP
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    oxidation-reduction process GO:0055114 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    cytosol GO:0005829 ISO
    integral component of membrane GO:0016021 IEA
    Golgi apparatus GO:0005794 IEA
    endoplasmic reticulum GO:0005783 ISO
    nucleus GO:0005634 ISO
    cytoskeleton GO:0005856 ISO
 Experiment description of studies that identified Dhcr24 in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dhcr24
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dhcr24 is involved
PathwayEvidenceSource
Cholesterol biosynthesis IEA Reactome





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