Gene description for Dhcr24
Gene name 24-dehydrocholesterol reductase
Gene symbol Dhcr24
Other names/aliases 2310076D10Rik
5830417J06Rik
mKIAA0018
Species Mus musculus
 Database cross references - Dhcr24
ExoCarta ExoCarta_74754
Entrez Gene 74754
UniProt Q8VCH6  
 Dhcr24 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Dhcr24
Molecular Function
    oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 ISO
    enzyme binding GO:0019899 ISO
    delta24(24-1) sterol reductase activity GO:0000246 ISO
    oxidoreductase activity GO:0016491 IEA
    peptide antigen binding GO:0042605 ISO
    flavin adenine dinucleotide binding GO:0050660 IEA
    delta24-sterol reductase activity GO:0050614 IEA
    catalytic activity GO:0003824 IEA
    UDP-N-acetylmuramate dehydrogenase activity GO:0008762 IEA
    oxidoreductase activity, acting on CH-OH group of donors GO:0016614 IEA
Biological Process
    amyloid precursor protein catabolic process GO:0042987 IMP
    skin development GO:0043588 IMP
    lipid metabolic process GO:0006629 IEA
    tissue development GO:0009888 ISO
    steroid metabolic process GO:0008202 ISO
    Ras protein signal transduction GO:0007265 ISO
    steroid biosynthetic process GO:0006694 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    cholesterol metabolic process GO:0008203 IMP
    male genitalia development GO:0030539 IMP
    sterol biosynthetic process GO:0016126 IEA
    negative regulation of cell proliferation GO:0008285 ISO
    sterol metabolic process GO:0016125 IMP
    plasminogen activation GO:0031639 IMP
    cholesterol biosynthetic process GO:0006695 ISO
    membrane organization GO:0061024 IMP
    protein localization GO:0008104 IMP
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    oxidation-reduction process GO:0055114 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    cytosol GO:0005829 ISO
    integral component of membrane GO:0016021 IEA
    Golgi apparatus GO:0005794 IEA
    endoplasmic reticulum GO:0005783 ISO
    nucleus GO:0005634 ISO
    cytoskeleton GO:0005856 ISO
 Experiment description of studies that identified Dhcr24 in exosomes
1
Experiment ID 263
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dhcr24
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dhcr24 is involved
PathwayEvidenceSource
Cholesterol biosynthesis IEA Reactome





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