Gene description for Zbtb4
Gene name zinc finger and BTB domain containing 4
Gene symbol Zbtb4
Other names/aliases 2310026P19Rik
9230111I22Rik
mKIAA1538
Species Mus musculus
 Database cross references - Zbtb4
ExoCarta ExoCarta_75580
Vesiclepedia VP_75580
Entrez Gene 75580
 Zbtb4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zbtb4
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IEA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    methyl-CpG binding GO:0008327 IEA
    methyl-CpG binding GO:0008327 ISO
    methyl-CpNpG binding GO:0010428 IEA
    methyl-CpNpG binding GO:0010428 ISO
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    sequence-specific DNA binding GO:0043565 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    regulation of DNA-templated transcription GO:0006355 IBA
    DNA damage response GO:0006974 IEA
    DNA damage response GO:0006974 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    chromosome GO:0005694 IEA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
 Experiment description of studies that identified Zbtb4 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zbtb4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cenpe  
Co-fractionation Mus musculus
2 CBFA2T3  
Two-hybrid Homo sapiens
3 Golga4  
Co-fractionation Mus musculus
4 Uaca  
Co-fractionation Mus musculus
5 Krt6a 16687
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Zbtb4 is involved
No pathways found





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