Gene description for Zbtb4
Gene name zinc finger and BTB domain containing 4
Gene symbol Zbtb4
Other names/aliases 2310026P19Rik
9230111I22Rik
mKIAA1538
Species Mus musculus
 Database cross references - Zbtb4
ExoCarta ExoCarta_75580
Entrez Gene 75580
 Zbtb4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zbtb4
Molecular Function
    methyl-CpNpG binding GO:0010428 ISO
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001227 ISO
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISO
    protein kinase binding GO:0019901 ISO
    protein homodimerization activity GO:0042803 ISO
    methyl-CpG binding GO:0008327 ISO
    sequence-specific DNA binding GO:0043565 ISO
Biological Process
    cellular response to DNA damage stimulus GO:0006974 ISO
    transcription from RNA polymerase II promoter GO:0006366 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Zbtb4 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zbtb4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Zbtb4 is involved
No pathways found





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