Gene description for Klf17
Gene name Kruppel-like factor 17
Gene symbol Klf17
Other names/aliases 7420700M05Rik
AA420409
AU043468
C85123
D4Ertd561e
Gzf
Zfp393
Species Mus musculus
 Database cross references - Klf17
ExoCarta ExoCarta_75753
Entrez Gene 75753
UniProt Q8CFA7  
 Klf17 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klf17
Molecular Function
    nucleic acid binding GO:0003676 IEA
    DNA binding GO:0003677 IEA
    metal ion binding GO:0046872 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    transcription from RNA polymerase II promoter GO:0006366 IDA
    gamete generation GO:0007276 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Klf17 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klf17
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Klf17 is involved
No pathways found





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