Gene description for Klf17
Gene name Kruppel-like factor 17
Gene symbol Klf17
Other names/aliases 7420700M05Rik
AA420409
AU043468
C85123
D4Ertd561e
Gzf
Zfp393
Species Mus musculus
 Database cross references - Klf17
ExoCarta ExoCarta_75753
Vesiclepedia VP_75753
Entrez Gene 75753
UniProt Q8CFA7  
 Klf17 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klf17
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    gamete generation GO:0007276 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Klf17 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klf17
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Klf17 is involved
No pathways found





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