Gene description for Zdhhc20
Gene name zinc finger, DHHC domain containing 20
Gene symbol Zdhhc20
Other names/aliases 5033406L14Rik
AI448102
B230110O18Rik
HK11
Species Mus musculus
 Database cross references - Zdhhc20
ExoCarta ExoCarta_75965
Vesiclepedia VP_75965
Entrez Gene 75965
UniProt Q5Y5T1  
 Zdhhc20 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Zdhhc20
Molecular Function
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    palmitoyltransferase activity GO:0016409 ISO
    protein-cysteine S-myristoyltransferase activity GO:0019705 IEA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IBA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISO
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISS
    protein-cysteine S-stearoyltransferase activity GO:0140439 IEA
Biological Process
    protein targeting to membrane GO:0006612 IBA
    synaptic vesicle maturation GO:0016188 IBA
    peptidyl-L-cysteine S-palmitoylation GO:0018230 ISO
    peptidyl-L-cysteine S-palmitoylation GO:0018230 ISS
    protein palmitoylation GO:0018345 ISO
    protein palmitoylation GO:0018345 ISS
    positive regulation by host of viral process GO:0044794 IEA
    positive regulation by host of viral process GO:0044794 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified Zdhhc20 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Zdhhc20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Zdhhc20 is involved
No pathways found





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