Gene description for Slc9a8
Gene name solute carrier family 9 (sodium/hydrogen exchanger), member 8
Gene symbol Slc9a8
Other names/aliases 1200006P13Rik
6430709P13Rik
AI182282
NHE-8
NHE8
Species Mus musculus
 Database cross references - Slc9a8
ExoCarta ExoCarta_77031
Entrez Gene 77031
UniProt Q8R4D1  
 Slc9a8 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Slc9a8
Molecular Function
    potassium:proton antiporter activity GO:0015386 IDA
    antiporter activity GO:0015297 IEA
    solute:proton antiporter activity GO:0015299 IEA
    sodium:proton antiporter activity GO:0015385 IDA
Biological Process
    transmembrane transport GO:0055085 IEA
    hydrogen ion transmembrane transport GO:1902600 IDA
    transport GO:0006810 IEA
    sodium ion transport GO:0006814 IDA
    ion transport GO:0006811 IEA
    potassium ion transmembrane transport GO:0071805 IDA
    potassium ion transport GO:0006813 IDA
    regulation of intracellular pH GO:0051453 IDA
    regulation of pH GO:0006885 IEA
    cation transport GO:0006812 IEA
    sodium ion transmembrane transport GO:0035725 IDA
Subcellular Localization
    membrane GO:0016020 IEA
    Golgi apparatus GO:0005794 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Slc9a8 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Slc9a8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc9a8 is involved
PathwayEvidenceSource
Sodium/Proton exchangers IEA Reactome





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