Gene description for Mvp
Gene name major vault protein
Gene symbol Mvp
Other names/aliases 2310009M24Rik
LRP
VAULT1
Species Mus musculus
 Database cross references - Mvp
ExoCarta ExoCarta_78388
Entrez Gene 78388
 Mvp identified in exosomes derived from the following tissue/cell type
Brain cancer cells 19109410    
 Gene ontology annotations for Mvp
Molecular Function
    protein kinase binding GO:0019901 ISO
    protein phosphatase binding GO:0019903 ISO
Biological Process
    ERBB signaling pathway GO:0038127 ISO
    negative regulation of protein tyrosine kinase activity GO:0061099 ISO
    cell proliferation GO:0008283 IMP
    protein activation cascade GO:0072376 IMP
    negative regulation of protein autophosphorylation GO:0031953 ISO
    negative regulation of signaling GO:0023057 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    ribonucleoprotein complex GO:0030529 IEA
    cytoskeleton GO:0005856 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Mvp in exosomes
1
Experiment ID 26
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|GAPDH|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
 Protein-protein interactions for Mvp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mvp is involved
No pathways found





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