Gene description for Helz
Gene name helicase with zinc finger domain
Gene symbol Helz
Other names/aliases 3110078M01Rik
9430093I07Rik
9630002H22Rik
AI851979
DRHC
Species Mus musculus
 Database cross references - Helz
ExoCarta ExoCarta_78455
Vesiclepedia VP_78455
Entrez Gene 78455
UniProt Q6DFV5  
 Helz identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Helz
Molecular Function
    RNA binding GO:0003723 IBA
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    regulatory ncRNA-mediated post-transcriptional gene silencing GO:0035194 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IBA
    P granule GO:0043186 IBA
 Experiment description of studies that identified Helz in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Helz
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Clk3  
Co-fractionation Mus musculus
2 Foxp3  
Affinity Capture-MS Mus musculus
3 Ncor2  
Co-fractionation Mus musculus
4 Smyd2  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
5 Pou5f1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Helz is involved
No pathways found





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