Gene description for Helz
Gene name helicase with zinc finger domain
Gene symbol Helz
Other names/aliases 3110078M01Rik
9430093I07Rik
9630002H22Rik
AI851979
DRHC
Species Mus musculus
 Database cross references - Helz
ExoCarta ExoCarta_78455
Entrez Gene 78455
UniProt Q6DFV5  
 Helz identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Helz
Molecular Function
    nucleotide binding GO:0000166 IEA
    metal ion binding GO:0046872 IEA
    hydrolase activity GO:0016787 IEA
    protein binding GO:0005515 IPI
    helicase activity GO:0004386 IEA
    poly(A) RNA binding GO:0044822 ISO
    ATP binding GO:0005524 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Helz in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Helz
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Helz is involved
No pathways found





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