Gene description for Adgra3
Gene name adhesion G protein-coupled receptor A3
Gene symbol Adgra3
Other names/aliases 8430414O08Rik
9530074E10Rik
Gpr124
Tem5
mKIAA1531
Species Mus musculus
 Database cross references - Adgra3
ExoCarta ExoCarta_78560
Vesiclepedia VP_78560
Entrez Gene 78560
UniProt Q91ZV8  
 Adgra3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Adgra3
Molecular Function
    G-protein coupled receptor activity GO:0004930 IEA
    transmembrane signaling receptor activity GO:0004888 IEA
    signal transducer activity GO:0004871 IEA
Biological Process
    central nervous system development GO:0007417 IMP
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    signal transduction GO:0007165 IEA
    regulation of chemotaxis GO:0050920 IMP
    endothelial cell migration GO:0043542 IMP
    sprouting angiogenesis GO:0002040 IMP
    positive regulation of endothelial cell migration GO:0010595 IDA
    cell surface receptor signaling pathway GO:0007166 IEA
    angiogenesis GO:0001525 IMP
    negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 IMP
    regulation of angiogenesis GO:0045765 IMP
    regulation of establishment of blood-brain barrier GO:0090210 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 IDA
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Adgra3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Adgra3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adgra3 is involved
No pathways found





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