Gene description for ROCK1
Gene name Rho-associated, coiled-coil containing protein kinase 1
Gene symbol ROCK1
Other names/aliases ROCK-I
p160ROCK
Species Bos taurus
 Database cross references - ROCK1
ExoCarta ExoCarta_785911
Vesiclepedia VP_785911
Entrez Gene 785911
 ROCK1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ROCK1
Molecular Function
    ATP binding GO:0005524 IEA
    small GTPase binding GO:0031267 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
Biological Process
    mitotic cytokinesis GO:0000281 IEA
    Rho protein signal transduction GO:0007266 IEA
    peptidyl-threonine phosphorylation GO:0018107 IEA
    cortical actin cytoskeleton organization GO:0030866 IEA
    actomyosin structure organization GO:0031032 IEA
    embryonic morphogenesis GO:0048598 IEA
    regulation of cell junction assembly GO:1901888 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    cytoplasmic stress granule GO:0010494 IEA
 Experiment description of studies that identified ROCK1 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ROCK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ROCK1 is involved
No pathways found





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