Gene description for ROCK1
Gene name Rho-associated, coiled-coil containing protein kinase 1
Gene symbol ROCK1
Other names/aliases ROCK-I
p160ROCK
Species Bos taurus
 Database cross references - ROCK1
ExoCarta ExoCarta_785911
Entrez Gene 785911
 ROCK1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ROCK1
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IEA
    GTP-Rho binding GO:0017049 IEA
    ATP binding GO:0005524 IEA
Biological Process
    positive regulation of cell maturation GO:1903431 IMP
    myoblast migration GO:0051451 ISS
    Rho protein signal transduction GO:0007266 IMP
    positive regulation of focal adhesion assembly GO:0051894 ISS
    regulation of establishment of cell polarity GO:2000114 IEA
    regulation of stress fiber assembly GO:0051492 IEA
    protein phosphorylation GO:0006468 IEA
Subcellular Localization
    lamellipodium GO:0030027 IEA
    Golgi membrane GO:0000139 IEA
    centriole GO:0005814 IEA
    plasma membrane GO:0005886 IEA
    bleb GO:0032059 IEA
    ruffle GO:0001726 IEA
 Experiment description of studies that identified ROCK1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ROCK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ROCK1 is involved
No pathways found





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