Gene description for Zc3hav1
Gene name zinc finger CCCH type, antiviral 1
Gene symbol Zc3hav1
Other names/aliases 1200014N16Rik
2900058M19Rik
9130009D18Rik
9830115L13Rik
ARTD13
D6Bwg1452e
ZAP
Species Mus musculus
 Database cross references - Zc3hav1
ExoCarta ExoCarta_78781
Vesiclepedia VP_78781
Entrez Gene 78781
UniProt Q3UPF5  
 Zc3hav1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Zc3hav1
Molecular Function
    RNA binding GO:0003723 IEA
    RNA binding GO:0003723 ISO
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IEA
    DEAD/H-box RNA helicase binding GO:0017151 ISO
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
    NAD+-protein ADP-ribosyltransferase activity GO:1990404 IBA
    NAD+-protein ADP-ribosyltransferase activity GO:1990404 ISS
Biological Process
    response to virus GO:0009615 IBA
    response to virus GO:0009615 IEA
    response to virus GO:0009615 ISO
    response to virus GO:0009615 ISO
    response to virus GO:0009615 ISS
    positive regulation of type I interferon production GO:0032481 IBA
    positive regulation of type I interferon production GO:0032481 IDA
    positive regulation of interferon-alpha production GO:0032727 ISO
    positive regulation of interferon-beta production GO:0032728 ISO
    positive regulation of ATP-dependent activity GO:0032781 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    negative regulation of viral genome replication GO:0045071 IEA
    negative regulation of viral genome replication GO:0045071 ISO
    negative regulation of viral genome replication GO:0045071 ISS
    innate immune response GO:0045087 IEA
    regulation of defense response to virus by host GO:0050691 ISO
    defense response to virus GO:0051607 IEA
    positive regulation of mRNA catabolic process GO:0061014 IBA
    positive regulation of mRNA catabolic process GO:0061014 IEA
    positive regulation of mRNA catabolic process GO:0061014 ISO
    positive regulation of mRNA catabolic process GO:0061014 ISS
    cellular response to exogenous dsRNA GO:0071360 IDA
    cellular response to virus GO:0098586 ISO
    positive regulation of RIG-I signaling pathway GO:1900246 ISO
    positive regulation of RIG-I signaling pathway GO:1900246 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Zc3hav1 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Zc3hav1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Atg16l1  
Affinity Capture-MS Mus musculus
4 Lin28a  
Co-fractionation Mus musculus
5 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Zc3hav1 is involved
No pathways found





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