Gene description for Apex1
Gene name	APEX nuclease (multifunctional DNA repair enzyme) 1
Gene symbol	Apex1
Other names/aliases	APE Apex REF-1
Species	Rattus norvegicus
Database cross references - Apex1
ExoCarta	ExoCarta_79116
Vesiclepedia	VP_79116
Entrez Gene	79116
UniProt	P43138
Apex1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Apex1

Molecular Function     DNA binding GO:0003677 IEA     DNA binding GO:0003677 ISO     DNA binding GO:0003677 ISS     damaged DNA binding GO:0003684 ISO     damaged DNA binding GO:0003684 ISS     double-stranded telomeric DNA binding GO:0003691 IEA     double-stranded telomeric DNA binding GO:0003691 ISO     transcription coactivator activity GO:0003713 IEA     transcription coactivator activity GO:0003713 ISO     transcription coactivator activity GO:0003713 ISS     RNA binding GO:0003723 IEA     DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 IBA     DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 ISO     DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 ISS     endonuclease activity GO:0004519 IEA     endonuclease activity GO:0004519 ISO     RNA endonuclease activity GO:0004521 IDA     exonuclease activity GO:0004527 IEA     protein binding GO:0005515 IPI     phosphoric diester hydrolase activity GO:0008081 IBA     phosphoric diester hydrolase activity GO:0008081 ISO     3'-5'-DNA exonuclease activity GO:0008296 IEA     3'-5'-DNA exonuclease activity GO:0008296 ISO     double-stranded DNA exodeoxyribonuclease activity GO:0008309 IEA     double-stranded DNA exodeoxyribonuclease activity GO:0008309 ISO     double-stranded DNA 3'-5' DNA exonuclease activity GO:0008311 IBA     3'-5' exonuclease activity GO:0008408 ISO     3'-5' exonuclease activity GO:0008408 ISS     oxidoreductase activity GO:0016491 IEA     oxidoreductase activity GO:0016491 ISO     oxidoreductase activity GO:0016491 ISS     site-specific endodeoxyribonuclease activity, specific for altered base GO:0016890 IEA     site-specific endodeoxyribonuclease activity, specific for altered base GO:0016890 ISO     site-specific endodeoxyribonuclease activity, specific for altered base GO:0016890 ISS     chromatin DNA binding GO:0031490 IEA     chromatin DNA binding GO:0031490 ISO     chromatin DNA binding GO:0031490 ISS     protein-containing complex binding GO:0044877 IPI     metal ion binding GO:0046872 IEA     metal ion binding GO:0046872 ISO     metal ion binding GO:0046872 ISS     NF-kappaB binding GO:0051059 IDA     class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0052720 IEA     class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0052720 ISO     class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0052720 ISS     phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands GO:0090580 IEA     phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands GO:0090580 ISO     DNA-(abasic site) binding GO:0140431 IEA     DNA-(abasic site) binding GO:0140431 ISO     DNA-(abasic site) binding GO:0140431 ISS Biological Process     telomere maintenance GO:0000723 ISO     DNA repair GO:0006281 IEA     DNA repair GO:0006281 ISO     DNA repair GO:0006281 ISS     base-excision repair GO:0006284 IBA     base-excision repair GO:0006284 ISO     DNA catabolic process GO:0006308 IEA     DNA catabolic process GO:0006308 ISO     DNA recombination GO:0006310 IEA     response to xenobiotic stimulus GO:0009410 IEP     negative regulation of smooth muscle cell migration GO:0014912 IMP     regulation of apoptotic process GO:0042981 IEA     regulation of apoptotic process GO:0042981 ISO     regulation of apoptotic process GO:0042981 ISS     regulation of mRNA stability GO:0043488 IEA     regulation of mRNA stability GO:0043488 ISO     regulation of mRNA stability GO:0043488 ISS     positive regulation of gene expression via chromosomal CpG island demethylation GO:0044029 IEA     positive regulation of gene expression via chromosomal CpG island demethylation GO:0044029 ISO     positive regulation of gene expression via chromosomal CpG island demethylation GO:0044029 ISS     cell redox homeostasis GO:0045454 IEA     cell redox homeostasis GO:0045454 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     cellular response to hydrogen peroxide GO:0070301 IDA     cellular response to hydrogen peroxide GO:0070301 IEP     cellular response to cAMP GO:0071320 IEP     telomere maintenance via base-excision repair GO:0097698 IEA     telomere maintenance via base-excision repair GO:0097698 ISO     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IMP     cellular response to Thyroid stimulating hormone GO:1904401 IEP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 ISO     transcription regulator complex GO:0005667 IDA     nucleolus GO:0005730 IEA     nucleolus GO:0005730 ISO     nucleolus GO:0005730 ISS     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     endoplasmic reticulum GO:0005783 IEA     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     nuclear speck GO:0016607 IEA     nuclear speck GO:0016607 ISO     nuclear speck GO:0016607 ISS     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     perinuclear region of cytoplasm GO:0048471 ISS