Gene description for Apex1
Gene name	APEX nuclease (multifunctional DNA repair enzyme) 1
Gene symbol	Apex1
Other names/aliases	APE Apex REF-1
Species	Rattus norvegicus
Database cross references - Apex1
ExoCarta	ExoCarta_79116
Entrez Gene	79116
UniProt	P43138
Apex1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Apex1

Molecular Function     protein binding GO:0005515 IPI     metal ion binding GO:0046872 ISS     protein complex binding GO:0032403 IPI     endonuclease activity GO:0004519 ISO     3'-5' exonuclease activity GO:0008408 ISS     NF-kappaB binding GO:0051059 IDA     phosphoric diester hydrolase activity GO:0008081 ISO     damaged DNA binding GO:0003684 ISS     chromatin DNA binding GO:0031490 ISS     endoribonuclease activity GO:0004521 IDA     site-specific endodeoxyribonuclease activity, specific for altered base GO:0016890 ISS     oxidoreductase activity GO:0016491 ISS     DNA binding GO:0003677 ISS     double-stranded DNA 3'-5' exodeoxyribonuclease activity GO:0008311 IBA     DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 ISS     poly(A) RNA binding GO:0044822 ISO     transcription coactivator activity GO:0003713 ISS Biological Process     RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IDA     aging GO:0007568 IDA     response to drug GO:0042493 IEP     regulation of transcription, DNA-templated GO:0006355 IEA     cellular response to peptide hormone stimulus GO:0071375 IEP     response to organonitrogen compound GO:0010243 IEP     DNA demethylation GO:0080111 ISS     nucleic acid phosphodiester bond hydrolysis GO:0090305 ISS     DNA repair GO:0006281 ISS     transcription, DNA-templated GO:0006351 IEA     DNA recombination GO:0006310 IEA     cellular response to organonitrogen compound GO:0071417 IEP     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IMP     cellular response to cAMP GO:0071320 IEP     base-excision repair GO:0006284 IBA     positive regulation of DNA repair GO:0045739 ISS     cellular response to hydrogen peroxide GO:0070301 IEP     negative regulation of smooth muscle cell migration GO:0014912 IMP     oxidation-reduction process GO:0055114 ISO     regulation of mRNA stability GO:0043488 ISS     cell redox homeostasis GO:0045454 ISO Subcellular Localization     mitochondrion GO:0005739 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 ISO     nucleolus GO:0005730 ISS     endoplasmic reticulum GO:0005783 IEA     transcription factor complex GO:0005667 IDA     nuclear speck GO:0016607 ISS     centrosome GO:0005813 ISO     perinuclear region of cytoplasm GO:0048471 ISS     cytoplasm GO:0005737 ISO