Gene description for Anxa6
Gene name annexin A6
Gene symbol Anxa6
Other names/aliases Anx6
CPB-II
Species Rattus norvegicus
 Database cross references - Anxa6
ExoCarta ExoCarta_79125
Entrez Gene 79125
 Anxa6 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Cortical neurones 16446100    
Hepatocytes 19367702    
 Gene ontology annotations for Anxa6
Molecular Function
    ligand-gated ion channel activity GO:0015276 ISO
    calcium-dependent phospholipid binding GO:0005544 TAS
    protein homodimerization activity GO:0042803 ISO
    protein complex binding GO:0032403 IPI
    GTP binding GO:0005525 ISO
    lipid binding GO:0008289 ISO
    calcium ion binding GO:0005509 IEA
    calcium-dependent protein binding GO:0048306 ISO
    cholesterol binding GO:0015485 ISO
    protein binding GO:0005515 IPI
Biological Process
    ion transmembrane transport GO:0034220 ISO
    calcium ion transport GO:0006816 ISO
    regulation of muscle contraction GO:0006937 ISO
    secretion GO:0046903 TAS
    protein homooligomerization GO:0051260 ISO
Subcellular Localization
    melanosome GO:0042470 IEA
    extracellular exosome GO:0070062 ISO
    focal adhesion GO:0005925 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    apical plasma membrane GO:0016324 IDA
    late endosome membrane GO:0031902 ISO
    membrane GO:0016020 ISO
    protein complex GO:0043234 IDA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 ISO
 Experiment description of studies that identified Anxa6 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 30
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16446100    
Organism Rattus norvegicus
Experiment description Exosomes are released by cultured cortical neurones.
Authors Faure J, Lachenal G, Court M, Hirrlinger J, Chatellard-Causse C, Blot B, Grange J, Schoehn G, Goldberg Y, Boyer V, Kirchhoff F, Raposo G, Garin J, Sadoul R
Journal name MCN
Publication year 2006
Sample Cortical neurones
Sample name Cortical neurones
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
4
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Anxa6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Anxa6 is involved
No pathways found





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