Gene description for DHRS11
Gene name dehydrogenase/reductase (SDR family) member 11
Gene symbol DHRS11
Other names/aliases ARPG836
SDR24C1
Species Homo sapiens
 Database cross references - DHRS11
ExoCarta ExoCarta_79154
Vesiclepedia VP_79154
Entrez Gene 79154
HGNC 28639
MIM 616159
UniProt Q6UWP2  
 DHRS11 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DHRS11
Molecular Function
    nucleotide binding GO:0000166 IEA
    3-keto sterol reductase activity GO:0000253 IDA
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IDA
    protein binding GO:0005515 IPI
    17-beta-ketosteroid reductase (NADPH) activity GO:0072555 IDA
    17-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0072582 IDA
Biological Process
    steroid biosynthetic process GO:0006694 IDA
    estrogen biosynthetic process GO:0006703 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified DHRS11 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DHRS11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NAPRT 93100
Co-fractionation Homo sapiens
2 TSTA3 7264
Co-fractionation Homo sapiens
3 HARS 3035
Co-fractionation Homo sapiens
4 TPI1 7167
Co-fractionation Homo sapiens
5 C7orf49  
Affinity Capture-MS Homo sapiens
6 GCLC 2729
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which DHRS11 is involved
No pathways found





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