Gene description for Gk
Gene name glycerol kinase
Gene symbol Gk
Other names/aliases ASTP
Gyk
Species Rattus norvegicus
 Database cross references - Gk
ExoCarta ExoCarta_79223
Entrez Gene 79223
UniProt Q63060  
 Gk identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Gk
Molecular Function
    histone binding GO:0042393 IDA
    ATP binding GO:0005524 IEA
    glycerol kinase activity GO:0004370 IBA
Biological Process
    triglyceride metabolic process GO:0006641 IBA
    response to drug GO:0042493 IEP
    glycerol metabolic process GO:0006071 IBA
    glycerol catabolic process GO:0019563 IEA
    response to cold GO:0009409 IEP
    response to organic substance GO:0010033 IEP
    glycerol-3-phosphate biosynthetic process GO:0046167 IBA
    glucose homeostasis GO:0042593 IEA
    response to ethanol GO:0045471 IDA
    phosphorylation GO:0016310 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IEA
    mitochondrion GO:0005739 IDA
    extracellular exosome GO:0070062 IEA
    mitochondrial outer membrane GO:0005741 IEA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Gk in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Gk
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gk is involved
No pathways found





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