Gene description for Serpind1
Gene name serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Gene symbol Serpind1
Other names/aliases rls2var1
Species Rattus norvegicus
 Database cross references - Serpind1
ExoCarta ExoCarta_79224
Entrez Gene 79224
UniProt Q64268  
 Serpind1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Serpind1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 TAS
    heparin binding GO:0008201 IEA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IBA
    biological_process GO:0008150 ND
    blood coagulation GO:0007596 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 IBA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified Serpind1 in exosomes
1
Experiment ID 95
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Serpind1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serpind1 is involved
PathwayEvidenceSource
Common Pathway of Fibrin Clot Formation IEA Reactome
Intrinsic Pathway of Fibrin Clot Formation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here