Gene description for Serpind1
Gene name serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Gene symbol Serpind1
Other names/aliases rls2var1
Species Rattus norvegicus
 Database cross references - Serpind1
ExoCarta ExoCarta_79224
Vesiclepedia VP_79224
Entrez Gene 79224
UniProt Q64268  
 Serpind1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Serpind1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 TAS
    heparin binding GO:0008201 IEA
Biological Process
    blood coagulation GO:0007596 IEA
    biological_process GO:0008150 ND
    negative regulation of endopeptidase activity GO:0010951 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified Serpind1 in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Serpind1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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