Gene description for Wwox
Gene name WW domain-containing oxidoreductase
Gene symbol Wwox
Other names/aliases 5330426P09Rik
9030416C10Rik
WOX1
Species Mus musculus
 Database cross references - Wwox
ExoCarta ExoCarta_80707
Vesiclepedia VP_80707
Entrez Gene 80707
UniProt Q91WL8  
 Wwox identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wwox
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 IEA
    enzyme binding GO:0019899 IPI
    enzyme binding GO:0019899 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    osteoblast differentiation GO:0001649 IMP
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of Wnt signaling pathway GO:0030178 ISO
    negative regulation of Wnt signaling pathway GO:0030178 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    skeletal system morphogenesis GO:0048705 IMP
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    cellular response to transforming growth factor beta stimulus GO:0071560 ISO
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IGI
    extrinsic apoptotic signaling pathway GO:0097191 IDA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    lysosome GO:0005764 IEA
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    microvillus GO:0005902 IEA
    microvillus GO:0005902 ISO
    RNA polymerase II transcription regulator complex GO:0090575 IDA
 Experiment description of studies that identified Wwox in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wwox
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Runx2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Traf3  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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