Gene description for Wwox
Gene name	WW domain-containing oxidoreductase
Gene symbol	Wwox
Other names/aliases	5330426P09Rik 9030416C10Rik WOX1
Species	Mus musculus
Database cross references - Wwox
ExoCarta	ExoCarta_80707
Entrez Gene	80707
UniProt	Q91WL8
Wwox identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Wwox

Molecular Function     very long-chain-3-hydroxyacyl-CoA dehydrogenase activity GO:0035380 IEA     D-xylose:NADP reductase activity GO:0032866 IEA     epoxide dehydrogenase activity GO:0018451 IEA     acetoin dehydrogenase activity GO:0019152 IEA     steroid dehydrogenase activity, acting on the CH-CH group of donors GO:0033765 IEA     oxidoreductase activity GO:0016491 IEA     3-ketoglucose-reductase activity GO:0048258 IEA     phenylcoumaran benzylic ether reductase activity GO:0032442 IEA     gluconate dehydrogenase activity GO:0008875 IEA     5-exo-hydroxycamphor dehydrogenase activity GO:0018452 IEA     L-arabinose:NADP reductase activity GO:0032867 IEA     RNA polymerase II transcription coactivator activity GO:0001105 IDA     L-xylulose reductase (NAD+) activity GO:0044105 IEA     protein binding GO:0005515 IPI     C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity GO:0000252 IEA     D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity GO:0052677 IEA     dihydrotestosterone 17-beta-dehydrogenase activity GO:0035410 IEA     aldo-keto reductase (NADP) activity GO:0004033 IEA     isocitrate dehydrogenase activity GO:0004448 IEA     D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity GO:0033709 IEA     2-hydroxytetrahydrofuran dehydrogenase activity GO:0018453 IEA     (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity GO:0034831 IEA     (R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 IEA     steroid dehydrogenase activity GO:0016229 IEA     (R)-2-hydroxyisocaproate dehydrogenase activity GO:0043713 IEA     mevaldate reductase activity GO:0004495 IEA     steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033764 IEA     3-hydroxymenthone dehydrogenase activity GO:0034840 IEA     L-arabinose 1-dehydrogenase (NADP+) activity GO:0044103 IEA     enzyme binding GO:0019899 ISO Biological Process     cellular response to transforming growth factor beta stimulus GO:0071560 ISO     negative regulation of Wnt signaling pathway GO:0030178 ISO     skeletal system morphogenesis GO:0048705 IMP     Wnt signaling pathway GO:0016055 IEA     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IDA     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP     osteoblast differentiation GO:0001649 IMP     apoptotic process GO:0006915 IEA     oxidation-reduction process GO:0055114 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     metabolic process GO:0008152 IEA     extrinsic apoptotic signaling pathway GO:0097191 IDA     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IGI Subcellular Localization     microvillus GO:0005902 ISO     cytoplasm GO:0005737 ISO     intracellular GO:0005622 IGI     Golgi apparatus GO:0005794 ISO     plasma membrane GO:0005886 ISO     cytosol GO:0005829 ISO     RNA polymerase II transcription factor complex GO:0090575 IDA     nucleus GO:0005634 ISO     mitochondrion GO:0005739 IDA