Gene description for Sec61a1
Gene name Sec61 alpha 1 subunit (S. cerevisiae)
Gene symbol Sec61a1
Other names/aliases Sec61a
Species Rattus norvegicus
 Database cross references - Sec61a1
ExoCarta ExoCarta_80843
Entrez Gene 80843
UniProt P61621  
 Sec61a1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Sec61a1
Molecular Function
    molecular_function GO:0003674 ND
    ribosome binding GO:0043022 ISO
Biological Process
    endoplasmic reticulum organization GO:0007029 ISO
    cell growth GO:0016049 ISO
    posttranslational protein targeting to membrane GO:0006620 ISO
    response to interferon-gamma GO:0034341 IEP
    SRP-dependent cotranslational protein targeting to membrane GO:0006614 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    rough endoplasmic reticulum GO:0005791 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Sec61a1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sec61a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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