Gene description for Slc21a4
Gene name kidney specific organic anion transporter
Gene symbol Slc21a4
Other names/aliases OAT-K1
OAT-K2
Slco1a3
rOAT-K1
rOAT-K11
rOAT-K13
rOAT-K14
rOAT-K2
rOAT-K3
rOAT-K5
rOAT-K6
rOAT-K7
rOAT-K8
rOAT-K9
Species Rattus norvegicus
 Database cross references - Slc21a4
ExoCarta ExoCarta_80899
Entrez Gene 80899
UniProt P70502  
 Slc21a4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Slc21a4
Molecular Function
    transporter activity GO:0005215 IEA
    organic anion transmembrane transporter activity GO:0008514 TAS
    methotrexate transporter activity GO:0015350 IDA
Biological Process
    methotrexate transport GO:0051958 IDA
    transport GO:0006810 IEA
    organic anion transport GO:0015711 TAS
    drug transport GO:0015893 IDA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Slc21a4 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Slc21a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc21a4 is involved
PathwayEvidenceSource
Recycling of bile acids and salts IEA Reactome
Transport of organic anions IEA Reactome





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