Gene description for Slc21a4
Gene name kidney specific organic anion transporter
Gene symbol Slc21a4
Other names/aliases OAT-K1
OAT-K2
Slco1a3
rOAT-K1
rOAT-K11
rOAT-K13
rOAT-K14
rOAT-K2
rOAT-K3
rOAT-K5
rOAT-K6
rOAT-K7
rOAT-K8
rOAT-K9
Species Rattus norvegicus
 Database cross references - Slc21a4
ExoCarta ExoCarta_80899
Vesiclepedia VP_80899
Entrez Gene 80899
UniProt P70502  
 Slc21a4 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Slc21a4
Molecular Function
    organic anion transmembrane transporter activity GO:0008514 IDA
    bile acid transmembrane transporter activity GO:0015125 IBA
    sodium-independent organic anion transmembrane transporter activity GO:0015347 IBA
    transmembrane transporter activity GO:0022857 IEA
Biological Process
    monoatomic ion transport GO:0006811 IEA
    bile acid and bile salt transport GO:0015721 IBA
    sodium-independent organic anion transport GO:0043252 IBA
    transmembrane transport GO:0055085 IEA
    monoatomic anion transmembrane transport GO:0098656 IDA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    basolateral plasma membrane GO:0016323 IBA
 Experiment description of studies that identified Slc21a4 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Slc21a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc21a4 is involved
No pathways found





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