Gene description for Trim23
Gene name tripartite motif-containing 23
Gene symbol Trim23
Other names/aliases 6330516O20Rik
AI450195
Arfd1
Species Mus musculus
 Database cross references - Trim23
ExoCarta ExoCarta_81003
Vesiclepedia VP_81003
Entrez Gene 81003
UniProt Q8BGX0  
 Trim23 identified in sEVs derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Trim23
Molecular Function
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    ubiquitin-protein transferase activity GO:0004842 ISO
    ubiquitin-protein transferase activity GO:0004842 ISS
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISO
    GTP binding GO:0005525 ISS
    zinc ion binding GO:0008270 IEA
    GDP binding GO:0019003 ISO
    GDP binding GO:0019003 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    ubiquitin protein ligase activity GO:0061630 IEA
    ubiquitin protein ligase activity GO:0061630 ISO
Biological Process
    intracellular protein transport GO:0006886 IBA
    positive regulation of autophagy GO:0010508 IEA
    positive regulation of autophagy GO:0010508 ISO
    vesicle-mediated transport GO:0016192 IBA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISO
    protein ubiquitination GO:0016567 ISS
    positive regulation of protein modification process GO:0031401 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified Trim23 in sEVs
1
Experiment ID 89
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors "Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M."
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
FACS
 Protein-protein interactions for Trim23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Trim23 is involved
No pathways found





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