Gene description for Ceacam1
Gene name carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Gene symbol Ceacam1
Other names/aliases BGPR
Bgp
CD66a
Ccam1
Species Rattus norvegicus
 Database cross references - Ceacam1
ExoCarta ExoCarta_81613
Entrez Gene 81613
UniProt P16573  
 Ceacam1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Ceacam1
Molecular Function
    virion binding GO:0046790 ISO
    protein homodimerization activity GO:0042803 ISO
    protein kinase binding GO:0019901 IPI
    virus receptor activity GO:0001618 ISO
Biological Process
    protein homotrimerization GO:0070207 IMP
    positive regulation by host of viral process GO:0044794 ISO
    positive regulation of NFAT protein import into nucleus GO:0051533 ISO
    viral entry into host cell GO:0046718 ISO
    signal transduction GO:0007165 IDA
    positive regulation of immunoglobulin secretion GO:0051024 ISO
    positive regulation of T cell proliferation GO:0042102 ISO
    negative regulation of JNK cascade GO:0046329 ISO
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 ISO
    cell adhesion GO:0007155 IEA
    Peyer's patch development GO:0048541 ISO
    negative regulation of T cell proliferation GO:0042130 ISO
    negative regulation by host of viral process GO:0044793 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 ISO
    positive regulation of activation-induced cell death of T cells GO:0070237 ISO
    positive regulation of JNK cascade GO:0046330 ISO
    negative regulation of cytokine production GO:0001818 ISO
    negative regulation of interleukin-2 production GO:0032703 ISO
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 ISO
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 ISO
    positive regulation of CD4-positive, alpha-beta T cell activation GO:2000516 ISO
    positive regulation of CD8-positive, alpha-beta T cell activation GO:2001187 ISO
    positive regulation of MAP kinase activity GO:0043406 IDA
    negative regulation by host of viral genome replication GO:0044828 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    integral component of membrane GO:0016021 ISO
    extracellular exosome GO:0070062 ISO
    brush border membrane GO:0031526 ISO
    ciliary membrane GO:0060170 ISO
    plasma membrane GO:0005886 ISO
    integral component of plasma membrane GO:0005887 TAS
    external side of plasma membrane GO:0009897 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Ceacam1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Ceacam1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ceacam1 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall IEA Reactome
Fibronectin matrix formation IEA Reactome





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