Gene description for Alox15
Gene name	arachidonate 15-lipoxygenase
Gene symbol	Alox15
Other names/aliases	12-LOX 15-LOX Alox12 Alox12l
Species	Rattus norvegicus
Database cross references - Alox15
ExoCarta	ExoCarta_81639
Vesiclepedia	VP_81639
Entrez Gene	81639
UniProt	Q02759
Alox15 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Alox15

Molecular Function     arachidonate 12(S)-lipoxygenase activity GO:0004052 IBA     arachidonate 12(S)-lipoxygenase activity GO:0004052 IDA     arachidonate 12(S)-lipoxygenase activity GO:0004052 IEA     arachidonate 12(S)-lipoxygenase activity GO:0004052 ISO     iron ion binding GO:0005506 IEA     iron ion binding GO:0005506 ISO     iron ion binding GO:0005506 ISS     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS     lipid binding GO:0008289 IEA     linoleate 13S-lipoxygenase activity GO:0016165 IBA     linoleate 13S-lipoxygenase activity GO:0016165 ISO     linoleate 13S-lipoxygenase activity GO:0016165 ISS     potassium channel inhibitor activity GO:0019870 TAS     hepoxilin-epoxide hydrolase activity GO:0047977 IDA     arachidonate 15-lipoxygenase activity GO:0050473 IBA     arachidonate 15-lipoxygenase activity GO:0050473 IDA     arachidonate 15-lipoxygenase activity GO:0050473 IEA     arachidonate 15-lipoxygenase activity GO:0050473 ISO     hepoxilin A3 synthase activity GO:0051120 IDA Biological Process     ossification GO:0001503 ISO     ossification GO:0001503 ISS     negative regulation of adaptive immune response GO:0002820 IEA     negative regulation of adaptive immune response GO:0002820 ISO     negative regulation of adaptive immune response GO:0002820 ISS     lipid metabolic process GO:0006629 ISO     phosphatidylethanolamine biosynthetic process GO:0006646 IEA     phosphatidylethanolamine biosynthetic process GO:0006646 ISO     phosphatidylethanolamine biosynthetic process GO:0006646 ISS     positive regulation of cell-substrate adhesion GO:0010811 ISO     positive regulation of cell-substrate adhesion GO:0010811 ISS     arachidonate metabolic process GO:0019369 IBA     arachidonate metabolic process GO:0019369 IDA     arachidonate metabolic process GO:0019369 IEA     arachidonate metabolic process GO:0019369 ISO     arachidonate metabolic process GO:0019369 NAS     lipoxygenase pathway GO:0019372 IBA     lipoxygenase pathway GO:0019372 IDA     lipoxygenase pathway GO:0019372 IEA     lipoxygenase pathway GO:0019372 ISO     fatty acid oxidation GO:0019395 ISO     fatty acid oxidation GO:0019395 ISS     bone mineralization GO:0030282 IEA     bone mineralization GO:0030282 ISO     bone mineralization GO:0030282 ISS     positive regulation of actin filament polymerization GO:0030838 IEA     positive regulation of actin filament polymerization GO:0030838 ISO     positive regulation of actin filament polymerization GO:0030838 ISS     positive regulation of heterotypic cell-cell adhesion GO:0034116 IMP     lipid oxidation GO:0034440 IBA     lipid oxidation GO:0034440 IEA     response to endoplasmic reticulum stress GO:0034976 IEA     response to endoplasmic reticulum stress GO:0034976 ISO     response to endoplasmic reticulum stress GO:0034976 ISS     regulation of peroxisome proliferator activated receptor signaling pathway GO:0035358 IEA     regulation of peroxisome proliferator activated receptor signaling pathway GO:0035358 ISO     regulation of peroxisome proliferator activated receptor signaling pathway GO:0035358 ISS     cellular response to interleukin-13 GO:0035963 ISO     cellular response to interleukin-13 GO:0035963 ISS     wound healing GO:0042060 IEA     wound healing GO:0042060 ISO     wound healing GO:0042060 ISS     regulation of membrane potential GO:0042391 TAS     apoptotic cell clearance GO:0043277 IEA     apoptotic cell clearance GO:0043277 ISO     apoptotic cell clearance GO:0043277 ISS     linoleic acid metabolic process GO:0043651 ISO     linoleic acid metabolic process GO:0043651 ISS     negative regulation of cell volume GO:0045794 TAS     icosanoid biosynthetic process GO:0046456 NAS     regulation of inflammatory response GO:0050727 ISO     regulation of inflammatory response GO:0050727 ISS     hepoxilin biosynthetic process GO:0051122 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     cellular response to calcium ion GO:0071277 ISO     cellular response to calcium ion GO:0071277 ISS     regulation of engulfment of apoptotic cell GO:1901074 IEA     regulation of engulfment of apoptotic cell GO:1901074 ISO     regulation of engulfment of apoptotic cell GO:1901074 ISS     lipoxin A4 biosynthetic process GO:2001303 IEA     lipoxin A4 biosynthetic process GO:2001303 ISO     lipoxin A4 biosynthetic process GO:2001303 ISS Subcellular Localization     cytoplasm GO:0005737 ISO     lipid droplet GO:0005811 IEA     lipid droplet GO:0005811 ISO     lipid droplet GO:0005811 ISS     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cytoplasmic side of plasma membrane GO:0009898 ISO     cytoplasmic side of plasma membrane GO:0009898 ISS     membrane GO:0016020 ISO     membrane GO:0016020 ISS     sarcolemma GO:0042383 ISS