Gene description for Aldh6a1
Gene name aldehyde dehydrogenase 6 family, member A1
Gene symbol Aldh6a1
Other names/aliases Mmsdh
Species Rattus norvegicus
 Database cross references - Aldh6a1
ExoCarta ExoCarta_81708
Entrez Gene 81708
UniProt Q02253  
 Aldh6a1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Aldh6a1
Molecular Function
    malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478 IDA
    aldehyde dehydrogenase (NAD) activity GO:0004029 IBA
    fatty-acyl-CoA binding GO:0000062 ISS
    poly(A) RNA binding GO:0044822 ISO
    thiolester hydrolase activity GO:0016790 IDA
    methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491 NAS
Biological Process
    thymine metabolic process GO:0019859 IDA
    brown fat cell differentiation GO:0050873 ISO
    beta-alanine catabolic process GO:0019484 IDA
    valine catabolic process GO:0006574 ISO
    oxidation-reduction process GO:0055114 IEA
    thymine catabolic process GO:0006210 ISO
    valine metabolic process GO:0006573 IDA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    extracellular exosome GO:0070062 ISO
    cellular_component GO:0005575 ND
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Aldh6a1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldh6a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldh6a1 is involved
No pathways found





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