Gene description for Fez1
Gene name fasciculation and elongation protein zeta 1 (zygin I)
Gene symbol Fez1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fez1
ExoCarta ExoCarta_81730
Entrez Gene 81730
UniProt P97577  
 Fez1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Fez1
Molecular Function
    protein kinase C binding GO:0005080 IPI
    protein N-terminus binding GO:0047485 IPI
    gamma-tubulin binding GO:0043015 ISO
    protein binding GO:0005515 IPI
Biological Process
    transport GO:0006810 IEA
    establishment of mitochondrion localization GO:0051654 IMP
    positive regulation of neuron differentiation GO:0045666 IDA
    axon guidance GO:0007411 TAS
    positive regulation of neuron projection development GO:0010976 IMP
    cellular response to growth factor stimulus GO:0071363 IEP
Subcellular Localization
    dendrite GO:0030425 IDA
    cell projection GO:0042995 IDA
    microtubule cytoskeleton GO:0015630 ISO
    microtubule GO:0005874 IEA
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IDA
    centrosome GO:0005813 ISO
    axon GO:0030424 IDA
 Experiment description of studies that identified Fez1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Fez1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fez1 is involved
No pathways found





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