Gene description for Fez1
Gene name fasciculation and elongation protein zeta 1 (zygin I)
Gene symbol Fez1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fez1
ExoCarta ExoCarta_81730
Vesiclepedia VP_81730
Entrez Gene 81730
UniProt P97577  
 Fez1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Fez1
Molecular Function
    protein kinase C binding GO:0005080 IPI
    protein binding GO:0005515 IPI
    gamma-tubulin binding GO:0043015 ISO
Biological Process
    mitochondrion organization GO:0007005 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    hippocampus development GO:0021766 IEP
    establishment of cell polarity GO:0030010 IMP
    establishment of mitochondrion localization GO:0051654 IMP
    positive regulation of anterograde axonal transport of mitochondrion GO:0061881 IMP
    cellular response to growth factor stimulus GO:0071363 IEP
    negative regulation of autophagosome assembly GO:1902902 ISO
    negative regulation of autophagosome assembly GO:1902902 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    Golgi apparatus GO:0005794 ISO
    centrosome GO:0005813 ISO
    microtubule GO:0005874 IEA
    plasma membrane GO:0005886 IEA
    axon GO:0030424 IBA
    axon GO:0030424 IDA
    dendrite GO:0030425 IDA
    growth cone GO:0030426 IDA
    cell projection GO:0042995 IDA
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Fez1 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Fez1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Prkcz  
Two-hybrid Rattus norvegicus
View the network image/svg+xml
 Pathways in which Fez1 is involved
No pathways found





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