Gene description for Rab13
Gene name RAB13, member RAS oncogene family
Gene symbol Rab13
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab13
ExoCarta ExoCarta_81756
Entrez Gene 81756
UniProt P35286  
 Rab13 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Reticulocytes 21828046    
 Gene ontology annotations for Rab13
Molecular Function
    protein kinase A catalytic subunit binding GO:0034236 IPI
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 ISS
    GTPase activity GO:0003924 ISO
Biological Process
    positive regulation of glucose import GO:0046326 IC
    endocytic recycling GO:0032456 ISS
    cortical actin cytoskeleton organization GO:0030866 IMP
    protein localization to plasma membrane GO:0072659 IDA
    protein localization to cell leading edge GO:1902463 ISS
    neuron projection development GO:0031175 ISO
    establishment of Sertoli cell barrier GO:0097368 IMP
    glucose homeostasis GO:0042593 IC
    cellular response to insulin stimulus GO:0032869 IMP
    trans-Golgi network to recycling endosome transport GO:0044795 ISS
    metabolic process GO:0008152 ISO
    Rab protein signal transduction GO:0032482 IBA
    protein kinase A signaling GO:0010737 ISO
    bicellular tight junction assembly GO:0070830 ISS
    intracellular protein transport GO:0006886 IBA
    endothelial cell chemotaxis GO:0035767 ISS
    establishment of protein localization to plasma membrane GO:0090002 ISS
    endosomal transport GO:0016197 ISS
Subcellular Localization
    bicellular tight junction GO:0005923 ISS
    insulin-responsive compartment GO:0032593 IDA
    transport vesicle membrane GO:0030658 IEA
    neuron projection GO:0043005 ISS
    intracellular GO:0005622 ISO
    recycling endosome GO:0055037 ISS
    trans-Golgi network GO:0005802 ISS
    Golgi apparatus GO:0005794 ISO
    endocytic vesicle GO:0030139 ISS
    lateral plasma membrane GO:0016328 ISS
    cytoplasm GO:0005737 ISO
    endosome GO:0005768 IBA
    recycling endosome membrane GO:0055038 IEA
    extracellular exosome GO:0070062 ISO
    cell-cell junction GO:0005911 ISO
    cell GO:0005623 ISO
    cytoplasmic vesicle membrane GO:0030659 TAS
    lamellipodium GO:0030027 ISS
    cytoplasmic vesicle GO:0031410 ISO
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified Rab13 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 100
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Rab13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab13 is involved
PathwayEvidenceSource
Translocation of GLUT4 to the plasma membrane IEA Reactome





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