Gene description for Rab11a
Gene name RAB11a, member RAS oncogene family
Gene symbol Rab11a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab11a
ExoCarta ExoCarta_81830
Entrez Gene 81830
UniProt P62494  
 Rab11a identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Rab11a
Molecular Function
    microtubule binding GO:0008017 ISO
    GTP binding GO:0005525 TAS
    GTPase activity GO:0003924 ISS
    myosin V binding GO:0031489 ISO
Biological Process
    regulation of vesicle-mediated transport GO:0060627 ISO
    establishment of protein localization to membrane GO:0090150 ISO
    regulation of long-term neuronal synaptic plasticity GO:0048169 IMP
    positive regulation of epithelial cell migration GO:0010634 ISO
    protein localization to plasma membrane GO:0072659 ISS
    establishment of vesicle localization GO:0051650 ISO
    positive regulation of axon extension GO:0045773 ISO
    melanosome transport GO:0032402 ISS
    mitotic spindle assembly GO:0090307 ISO
    establishment of protein localization to organelle GO:0072594 ISO
    exosomal secretion GO:1990182 ISO
    vesicle-mediated transport GO:0016192 ISO
    astral microtubule organization GO:0030953 ISO
    regulation of protein transport GO:0051223 IMP
    Rab protein signal transduction GO:0032482 IBA
    metabolic process GO:0008152 ISS
    regulation of multivesicular body size GO:0010796 ISO
    neuron projection development GO:0031175 ISS
    multivesicular body assembly GO:0036258 ISO
    exocytosis GO:0006887 IBA
    mitotic metaphase plate congression GO:0007080 ISO
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 ISO
    intracellular protein transport GO:0006886 IBA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    axon GO:0030424 ISO
    cleavage furrow GO:0032154 ISS
    trans-Golgi network GO:0005802 ISO
    kinetochore microtubule GO:0005828 ISO
    multivesicular body GO:0005771 ISO
    transport vesicle GO:0030133 IDA
    cell GO:0005623 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    mitochondrion GO:0005739 ISO
    phagocytic vesicle membrane GO:0030670 IEA
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    vesicle GO:0031982 ISO
    recycling endosome GO:0055037 ISO
    spindle pole GO:0000922 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasmic vesicle GO:0031410 ISO
    Golgi apparatus GO:0005794 ISO
    recycling endosome membrane GO:0055038 IEA
    phagocytic vesicle GO:0045335 ISS
    protein complex GO:0043234 ISO
 Experiment description of studies that identified Rab11a in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab11a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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