Gene description for Rab11a
Gene name RAB11a, member RAS oncogene family
Gene symbol Rab11a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab11a
ExoCarta ExoCarta_81830
Vesiclepedia VP_81830
Entrez Gene 81830
UniProt P62494  
 Rab11a identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Rab11a
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IDA
    GTPase activity GO:0003924 IEA
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    G protein activity GO:0003925 ISO
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IDA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 TAS
    microtubule binding GO:0008017 ISO
    protein domain specific binding GO:0019904 ISO
    myosin V binding GO:0031489 ISO
    dynein light intermediate chain binding GO:0051959 ISO
    dynein light intermediate chain binding GO:0051959 ISS
Biological Process
    exocytosis GO:0006887 IBA
    mitotic metaphase chromosome alignment GO:0007080 ISO
    positive regulation of epithelial cell migration GO:0010634 ISO
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 ISO
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 ISO
    astral microtubule organization GO:0030953 ISO
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISS
    intracellular cholesterol transport GO:0032367 ISS
    melanosome transport GO:0032402 IBA
    melanosome transport GO:0032402 ISO
    melanosome transport GO:0032402 ISS
    regulation of cytokinesis GO:0032465 ISO
    protein localization to cell surface GO:0034394 ISO
    multivesicular body assembly GO:0036258 ISO
    regulation of long-term neuronal synaptic plasticity GO:0048169 IMP
    regulation of protein transport GO:0051223 IMP
    establishment of vesicle localization GO:0051650 ISO
    regulation of vesicle-mediated transport GO:0060627 ISO
    early endosome to recycling endosome transport GO:0061502 ISO
    protein localization to cilium GO:0061512 ISO
    protein localization to cilium GO:0061512 ISS
    protein transmembrane transport GO:0071806 ISO
    establishment of protein localization to organelle GO:0072594 ISO
    protein localization to plasma membrane GO:0072659 ISO
    protein localization to plasma membrane GO:0072659 ISS
    establishment of protein localization to membrane GO:0090150 ISO
    mitotic spindle assembly GO:0090307 ISO
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IBA
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IDA
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IMP
    vesicle-mediated transport in synapse GO:0099003 IDA
    vesicle-mediated transport in synapse GO:0099003 IMP
    synaptic vesicle endosomal processing GO:0099532 EXP
    synaptic vesicle endosomal processing GO:0099532 IDA
    synaptic vesicle endosomal processing GO:0099532 IMP
    amyloid-beta clearance by transcytosis GO:0150093 ISO
    regulation of cilium assembly GO:1902017 ISO
    regulation of cilium assembly GO:1902017 ISS
    regulation of early endosome to recycling endosome transport GO:1902954 ISO
    regulation of early endosome to recycling endosome transport GO:1902954 ISS
    positive regulation of protein localization to plasma membrane GO:1903078 IMP
    positive regulation of mitotic cytokinetic process GO:1903438 ISO
    regulation of protein localization to centrosome GO:1904779 ISO
    regulation of protein localization to centrosome GO:1904779 ISS
    exosomal secretion GO:1990182 ISO
    regulation of endocytic recycling GO:2001135 ISO
    regulation of endocytic recycling GO:2001135 ISS
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    spindle pole GO:0000922 ISO
    cytoplasm GO:0005737 ISO
    multivesicular body GO:0005771 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IEA
    trans-Golgi network GO:0005802 ISO
    trans-Golgi network GO:0005802 ISS
    centrosome GO:0005813 ISO
    centrosome GO:0005813 ISS
    centriole GO:0005814 ISO
    kinetochore microtubule GO:0005828 ISO
    cytosol GO:0005829 ISS
    membrane GO:0016020 ISO
    transport vesicle GO:0030133 IBA
    endocytic vesicle membrane GO:0030666 ISO
    endocytic vesicle membrane GO:0030666 ISS
    synaptic vesicle membrane GO:0030672 EXP
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IEA
    cytoplasmic vesicle GO:0031410 ISO
    vesicle GO:0031982 ISO
    cleavage furrow GO:0032154 IEA
    cleavage furrow GO:0032154 ISO
    cleavage furrow GO:0032154 ISS
    trans-Golgi network membrane GO:0032588 ISO
    trans-Golgi network membrane GO:0032588 ISS
    protein-containing complex GO:0032991 ISO
    centriolar satellite GO:0034451 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    phagocytic vesicle GO:0045335 IEA
    phagocytic vesicle GO:0045335 ISO
    phagocytic vesicle GO:0045335 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
    recycling endosome GO:0055037 IDA
    recycling endosome GO:0055037 ISO
    recycling endosome membrane GO:0055038 IEA
    extracellular exosome GO:0070062 ISO
    exocytic vesicle GO:0070382 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    presynaptic endosome GO:0098830 EXP
    presynaptic endosome GO:0098830 IDA
    presynaptic endosome GO:0098830 IMP
    postsynaptic recycling endosome GO:0098837 IBA
    postsynaptic recycling endosome GO:0098837 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Rab11a in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab11a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNA5  
Affinity Capture-Western Homo sapiens
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