Gene description for Plekha3
Gene name pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
Gene symbol Plekha3
Other names/aliases FAPP1
Species Mus musculus
 Database cross references - Plekha3
ExoCarta ExoCarta_83435
Vesiclepedia VP_83435
Entrez Gene 83435
UniProt Q9ERS4  
 Plekha3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Plekha3
Molecular Function
    phospholipid binding GO:0005543 ISO
    1-phosphatidylinositol binding GO:0005545 IDA
    lipid binding GO:0008289 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    Golgi apparatus GO:0005794 ISO
 Experiment description of studies that identified Plekha3 in exosomes
1
Experiment ID 15
MISEV standards
EM
EV Biophysical techniques
CD63
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Plekha3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plekha3 is involved
No pathways found





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