Gene description for Aifm1
Gene name apoptosis-inducing factor, mitochondrion-associated 1
Gene symbol Aifm1
Other names/aliases Aif
Pdcd8
Species Rattus norvegicus
 Database cross references - Aifm1
ExoCarta ExoCarta_83533
Entrez Gene 83533
UniProt Q9JM53  
 Aifm1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Aifm1
Molecular Function
    oxidoreductase activity, acting on NAD(P)H GO:0016651 ISO
    protein dimerization activity GO:0046983 IEA
    FAD binding GO:0071949 ISO
    NAD(P)H oxidase activity GO:0016174 ISO
    DNA binding GO:0003677 ISO
Biological Process
    cell redox homeostasis GO:0045454 IEA
    neuron apoptotic process GO:0051402 ISO
    mitochondrial respiratory chain complex I assembly GO:0032981 ISO
    apoptotic process GO:0006915 ISO
    oxidation-reduction process GO:0055114 ISO
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
    positive regulation of cell death GO:0010942 ISO
    regulation of apoptotic DNA fragmentation GO:1902510 ISO
    neuron differentiation GO:0030182 ISO
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISS
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    mitochondrial intermembrane space GO:0005758 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified Aifm1 in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Aifm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aifm1 is involved
No pathways found





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