Gene description for Abcb11
Gene name ATP-binding cassette, subfamily B (MDR/TAP), member 11
Gene symbol Abcb11
Other names/aliases Bsep
Spgp
Species Rattus norvegicus
 Database cross references - Abcb11
ExoCarta ExoCarta_83569
Entrez Gene 83569
UniProt O70127  
 Abcb11 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Abcb11
Molecular Function
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    canalicular bile acid transmembrane transporter activity GO:0015126 IDA
    protein binding GO:0005515 IPI
    drug transmembrane transporter activity GO:0015238 IDA
    ATP binding GO:0005524 IEA
Biological Process
    transmembrane transport GO:0055085 IEA
    response to oxidative stress GO:0006979 IEP
    canalicular bile acid transport GO:0015722 IDA
    response to drug GO:0042493 IMP
    response to estrogen GO:0043627 IEP
    drug export GO:0046618 IDA
    drug transmembrane transport GO:0006855 IDA
    metabolic process GO:0008152 IEA
    bile acid and bile salt transport GO:0015721 IEA
Subcellular Localization
    apical part of cell GO:0045177 ISO
    integral component of membrane GO:0016021 IEA
    extracellular exosome GO:0070062 ISO
    intercellular canaliculus GO:0046581 ISO
    Golgi membrane GO:0000139 IDA
    plasma membrane GO:0005886 IDA
    apical plasma membrane GO:0016324 IDA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Abcb11 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Abcb11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abcb11 is involved
No pathways found





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