Gene description for AKR1E2
Gene name aldo-keto reductase family 1, member E2
Gene symbol AKR1E2
Other names/aliases AKR1CL2
AKRDC1
LoopADR
hTSP
htAKR
Species Homo sapiens
 Database cross references - AKR1E2
ExoCarta ExoCarta_83592
Entrez Gene 83592
HGNC 23437
UniProt Q96JD6  
 AKR1E2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for AKR1E2
Molecular Function
    1,5-anhydro-D-fructose reductase activity GO:0050571 IEA
Biological Process
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified AKR1E2 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AKR1E2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AKR1E2 is involved
No pathways found





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